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SFRP2 — WNT3
Pathways - manually collected, often from reviews:
-
KEGG Wnt signaling pathway:
SFRP1/SFRP2/SFRP4/SFRP5
→
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
(protein-protein, inhibition)
Text-mined interactions from Literome
La et al., Di Yi Jun Yi Da Xue Xue Bao 2004
(Liver Neoplasms) :
[ Anti-oncogene p53 induced expression of
secreted frizzled related protein , a
Wnt signaling
inhibitor ]
Marsit et al., Cancer Res 2005
(Disease Progression...) :
Epigenetic silencing of the secreted frizzled receptor proteins (
SFRP ), antagonists of the WNT pathway,
leads to constitutive
WNT signaling, altering cell morphology and motility
Rodriguez et al., Nat Neurosci 2005
:
Here we show that
secreted Frizzled related protein 1 ( SFRP1 ), a proposed
Wnt signaling
inhibitor , can directly modify and reorient the growth of chick and Xenopus laevis retinal ganglion cell axons
Zi et al., Cancer Res 2005
(Neoplasm Invasiveness...) :
The ability of
Frzb/secreted Frizzled related protein 3 ( sFRP3 ) to
inhibit Wnt signaling and the localization of Frzb/sFRP3 on chromosome 2q to a region frequently deleted in cancers have led some investigators to hypothesize that Frzb/sFRP3 is a tumor suppressor gene
Satoh et al., Development 2006
:
This study suggests that
Wnt regulation by Sfrp1 and
Sfrp2 is required for embryonic patterning
Nojima et al., Oncogene 2007
(Carcinoma...) :
Frequent epigenetic inactivation of
SFRP genes and constitutive
activation of
Wnt signaling in gastric cancer
Gumz et al., Clin Cancer Res 2007
(Carcinoma, Renal Cell...) :
In an effort to gain a better understanding of signaling events in clear cell RCC ( cRCC ), we investigated the antitumor activity of
secreted frizzled related protein 1 ( sFRP1 ), a negative
regulator of
Wnt signaling
Schlange et al., Breast Cancer Res 2007
(Breast Neoplasms) :
Most breast tumors show hypermethylation of the promoter region of
secreted Frizzled related protein 1 ( sFRP1 ), a negative
WNT pathway
regulator , leading to downregulation of its expression
Deb et al., Stem Cells 2008
:
We show that the inhibitory
effects of
SFRP2 on
Wnt transcription are secondary to interruption of a positive feedback effect of Wnt3a on its own transcription
Dufourcq et al., Am J Pathol 2008
(Neovascularization, Pathologic) :
Our previous work has shown a role for
secreted Frizzled related protein-1 ( sFRP-1 ), a proposed
Wnt signaling
inhibitor , in neovascularization after an ischemic event and demonstrated its role as a potent angiogenic factor
Satoh et al., Genesis 2008
:
Sfrp1,
Sfrp2 , and Sfrp5
regulate the
Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse
Morello et al., J Cell Physiol 2008
(Syndactyly) :
Sfrp2 can also
repress canonical
Wnt signaling by Wnt1, Wnt9a, and Wnt4 in vitro
Trenkmann et al., Ann Rheum Dis 2011
(Arthritis, Rheumatoid) :
As a target gene of EZH2 the authors identified
secreted frizzled related protein 1 ( SFRP1 ), an
inhibitor of
Wnt signalling, which is associated with the activation of RASF, and show that SFRP1 expression correlates with the occupation of its promoter with activating and silencing histone marks
Mao et al., Invest Ophthalmol Vis Sci 2012
(Wnt Signaling Pathway) :
We previously discovered elevated levels of
secreted frizzled related protein 1 ( sFRP1 ), the
Wnt signaling pathway
inhibitor , in the glaucomatous trabecular meshwork ( GTM ), and found that key canonical Wnt signaling pathway genes are expressed in the trabecular meshwork ( TM )
Shen et al., PloS one 2012
:
Such a loss was averted by treatment of
secreted Frizzled related protein 1 ( sFRP1 ), an
inhibitor of
Wnt signaling
Yamada et al., Biomaterials 2013
(Wnt Signaling Pathway) :
In addition,
SFRP3 inhibited non-canonical
WNT signalling by binding WNT5A, which is a representative non-canonical WNT protein