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SIRT1 — TNF

Text-mined interactions from Literome

Van Gool et al., Nat Med 2009 : Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin dependent manner
Shen et al., Am J Physiol Gastrointest Liver Physiol 2009 (Liver Diseases, Alcoholic) : Role of SIRT1 in regulation of LPS- or two ethanol metabolites induced TNF-alpha production in cultured macrophage cell lines ... In the present study, we examined the role of SIRT1 signaling in TNF-alpha generation stimulated by either lipopolysaccharide (LPS), acetaldehyde (AcH), or acetate ( two major metabolites of ethanol ) in two cultured macrophage cell lines ... Taken together, our findings suggest that SIRT1-NF-kappaB signaling is involved in regulating LPS- and metabolites-of-ethanol mediated TNF-alpha production in rat Kupffer cells and in murine macrophages
Yoshizaki et al., Am J Physiol Endocrinol Metab 2010 (Inflammation...) : We also demonstrate that SIRT1 activators inhibit LPS stimulated inflammatory pathways, as well as secretion of TNFalpha , in a SIRT1 dependent manner in RAW264.7 cells and in primary intraperitoneal macrophages
Zhang et al., Biochem Biophys Res Commun 2010 (Inflammation) : Involvement of the p65/RelA subunit of NF-kappaB in TNF-alpha induced SIRT1 expression in vascular smooth muscle cells ... Our study indicates that p65/RelA mediates the TNF-alpha induced elevated expression of SIRT1 in VSMCs, shedding new light on the regulation of SIRT1 under inflammatory conditions ... In the present research, we showed that levels of SIRT1 mRNA and protein expression increased in TNF-alpha treated VSMCs. Overexpression of the p65/RelA subunit of NF-kappaB, a TNF-alpha activated inflammatory transcription factor, in A7r5 cells, upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity, while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity, but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity
Oppenheimer et al., Arthritis Rheum 2012 (Osteoarthritis, Knee) : 75-kd sirtuin 1 blocks tumor necrosis factor a-mediated apoptosis in human osteoarthritic chondrocytes
Zhu et al., PloS one 2011 (Inflammation) : Activation of Sirt1 by resveratrol inhibits TNF-a induced inflammation in fibroblasts
Saini et al., Exp Physiol 2012 : C2C12 myoblasts, a subclone of the C2 cell line produced for their differentiation potential and used to examine intrinsic ageing, unlike C2 cells, do not die in the presence of TNF-a and do not upregulate Sirt1
Yang et al., Cell Physiol Biochem 2012 : Conclusion : The present study provides the direct evidence that SIRT1 can inhibit TNF-a- induced CD40 expression in CRL-1730 endothelial cells by deacetylating the RelA/p65 subunit of NF-?B at lysine 310, which provides new insights into understanding of the anti-inflammatory and anti-athroscerotic actions of SIRT1
Zhou et al., J Clin Invest 2013 (Polycystic Kidney, Autosomal Dominant) : SIRT1 was upregulated through c-MYC in embryonic and postnatal Pkd1-mutant mouse renal epithelial cells and tissues and could be induced by TNF-a , which is present in cyst fluid during cyst development