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RELA — SLPI

Text-mined interactions from Literome

Lentsch et al., Gastroenterology 1999 (Inflammation...) : SLPI also suppressed activation of the transcription factor NF-kappaB in liver
Mulligan et al., Am J Pathol 2000 (Acute Disease...) : The in vivo suppressive effects of SLPI mutants on lung vascular permeability, neutrophil recruitment, and NF-kappaB activation appear to be most closely related to their trypsin inhibiting activity ... These data suggest that the suppressive effects of SLPI on the intrapulmonary activation of NF-kappaB and neutrophil recruitment into the lung may be linked to their antiprotease activity, directed, perhaps, at the intracellular proteases
Ward et al., Mol Cell Biochem 2002 (Acute Disease...) : IL-10 and IL-13 attenuate NF-kappaB activation by interfering with breakdown of IkappaBalpha, while SLPI likewise suppresses NF-kappaB activation, but by interfering with breakdown of IkappaBbeta ... Antibody induced blockade of IL-10, IL-13 or SLPI enhances NF-KB activation in lung and exacerbates the lung inflammatory response and injury
Sano et al., Cytokine 2003 : Effects of secretory leukocyte protease inhibitor on the tumor necrosis factor-alpha production and NF-kappaB activation of lipopolysaccharide stimulated macrophages ... 1/2 SLPI weakly increased Mphi TNF-alpha production in response to LPS signaling and potentiated the LPS induced activation of NF-kappaB , especially the binding of p65-p50 heterodimers to the DNA kappaB sites, suggesting that LPS-hyporesponsiveness of Lps ( d ) Mphis is not due to the overexpression of SLPI
Taggart et al., J Exp Med 2005 : We have previously shown that SLPI can inhibit LPS induced NF-kappaB activation in monocytic cells by inhibiting degradation of IkappaBalpha without affecting the LPS induced phosphorylation and ubiquitination of IkappaBalpha ... Here, we present evidence to show that upon incubation with peripheral blood monocytes ( PBMs ) and the U937 monocytic cell line, SLPI enters the cells, becoming rapidly localized to the cytoplasm and nucleus, and affects NF-kappaB activation by binding directly to NF-kappaB binding sites in a site-specific manner ... Therefore, SLPI inhibition of NF-kappaB activation is mediated, in part, by competitive binding to the NF-kappaB consensus binding site
Okabe et al., J Endod 2006 : These results suggest that NF- kappaB and Smad7 play an important role in the down regulation of ALP activity by TNF-alpha on HDP cells
Sehnert et al., Arthritis Res Ther 2006 : Concomitantly, ALP suppressed the IL-1beta induced NF-kappaB activation and the upregulation of E-selectin expression in glEND.2 cells in vitro
Fahey et al., Mucosal Immunol 2008 : As SLPI is known to inhibit NF-kB expression, these findings suggest that E ( 2 ) inhibition of proinflammatory cytokines may be mediated through SLPI regulation of NF-kB
Choi et al., J Endod 2009 (Pulpitis...) : SLPI also inhibited the LPS induced activation of NF-kappaB in MDPC-23
Lentsch et al., Am J Pathol 1999 (Pneumonia) : The presence of SLPI caused greatly reduced activation ( ie, nuclear translocation ) of the transcription nuclear factor-kappaB (NF-kappaB) in lung cells but did not suppress activation of lung mitogen activated protein kinase ... Finally, in the lung inflammatory model used, the presence of anti-SLPI caused accentuated activation of NF-kappaB