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CDK4 — SMAD2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: SMAD2 — CDK4 Matsuura et al., Nature 2004
• IRef Bind_translation Interaction: SMAD2 — CDK4 (experimental interaction detection) Matsuura et al., Nature 2004
• IRef Biogrid Interaction: SMAD2 — CDK4 (direct interaction, enzymatic study) Matsuura et al., Nature 2004
• IRef Hprd Interaction: SMAD2 — CDK4 (in vitro) Matsuura et al., Nature 2004
• IRef Ophid Interaction: SMAD2 — CDK4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Zhang et al., J Neurosurg 2006 (Glioma) : Overall, the expression of the Smad2 and Smad3 proteins was low in the glioma cell lines, the phosphorylation and nuclear translocation of Smad2 and Smad3 were impaired, and the TGFbeta receptor signal did not affect the expression of the SnoN, p21, p15, cyclin D1, and CDK4 proteins
Cheng et al., Chem Biol 2012 (MAP Kinase Signaling System) : We found that indirubin derivative E738 inhibited both TGFß and BMP pathways through ubiquitin-proteasome mediated depletion of total R-Smad pools, although phospho-R-Smad levels were initially stabilized by GSK3ß and cyclin dependent kinase inhibition