◀ Back to IFNG

IFNG — SMAD3

Text-mined interactions from Literome

Ulloa et al., Nature 1999 : IFN-gamma inhibits the TGF beta induced phosphorylation of Smad3 and its attendant events, namely, the association of Smad3 with Smad4, the accumulation of Smad3 in the nucleus, and the activation of TGFbeta-responsive genes
Sumiyoshi et al., J Dermatol Sci 2003 : TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha induced TARC ( CCL17 ) production in HaCaT cells
Gu et al., Acta Pharmacol Sin 2004 : IFN-gamma 200 microg/L did not block TGF-beta1 stimulated Smad2/3 phosphorylation and their nuclear translocation
Thomas et al., Cancer Cell 2005 : Repression of granzyme B and interferon-gamma involves binding of TGF-beta activated Smad and ATF1 transcription factors to their promoter regions, indicating direct and selective regulation by the TGF-beta/Smad pathway
Tanaka et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental) : TGF-beta mediated Smad transcriptional activity was severely inhibited in SOCS1-deficient cells in the presence of IFN-gamma ... Induction of SOCS3 can partly explain IFN-gamma mediated STAT3 suppression, while other mechanism ( s ) will be involved in IFN-gamma mediated Smad suppression
Trotta et al., J Immunol 2008 : TGF-beta treatment induced SMAD3 phosphorylation, and ectopic overexpression of SMAD3 resulted in a significant decrease in IFN-gamma gene expression following CD16 activation with or without IL-12 or IL-2
Takimoto et al., J Immunol 2010 (Inflammation) : In this study, we generated T cell-specific Smad2 conditional knockout ( KO ) mice and unexpectedly found that Smad2 and Smad3 were redundantly essential for TGF-beta mediated induction of Foxp3 expressing regulatory T cells and suppression of IFN-gamma production in CD4 ( + ) T cells