Sumiyoshi et al., J Dermatol Sci 2003
:
TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha induced TARC ( CCL17 ) production in HaCaT cells
Thomas et al., Cancer Cell 2005
:
Repression of granzyme B and interferon-gamma involves binding of TGF-beta activated Smad and ATF1 transcription factors to their promoter regions, indicating direct and selective regulation by the TGF-beta/Smad pathway
Tanaka et al., J Immunol 2008
(Encephalomyelitis, Autoimmune, Experimental) :
TGF-beta mediated Smad transcriptional activity was severely inhibited in SOCS1-deficient cells in the presence of IFN-gamma ... Induction of SOCS3 can partly explain IFN-gamma mediated STAT3 suppression, while other mechanism ( s ) will be involved in IFN-gamma mediated Smad suppression