◀ Back to SLC22A3

SLC22A3 — SMAD6

Text-mined interactions from Literome

Rhyu et al., J Am Soc Nephrol 2005 (Fibrosis...) : Phosphorylation of Smad proteins and/or mitogen activated protein kinases ( MAPK ) is required for TGF-beta1 induced EMT
Desgrosellier et al., Dev Biol 2005 : Smad6 , an inhibitor of Smad signaling downstream of ALK2, but not ALK5, inhibited EMT in AV cushion endocardial cells ... Smad6, an inhibitor of Smad signaling downstream of ALK2, but not ALK5, inhibited EMT in AV cushion endocardial cells ... These data suggest that ALK2 activation may stimulate EMT in the AV cushion and that Smad6 may act downstream of ALK2 to negatively regulate EMT
Liu et al., Perit Dial Int 2008 (Fibrosis...) : Phosphorylation of Smad proteins is required for TGFbeta1 induced EMT
Miyazono et al., Proc Jpn Acad Ser B Phys Biol Sci 2009 (Disease Progression...) : Multiple transcription factors, including deltaEF1/ZEB1, SIP1/ZEB2, and Snail/SNAI1, are induced by TGF-beta-Smad signaling and play critical roles in TGF-beta induced EMT ... In addition, both non-Smad signaling activated by TGF-beta and cross-talk with other signaling pathways play important roles in induction of EMT
Zhou et al., J Am Soc Nephrol 2010 : Because Smad proteins transduce TGF-beta signaling from the cytosol to the nucleus and HSP72 assists in protein folding and facilitates nuclear translocation, we investigated whether HSP72 inhibits TGF-beta induced EMT by modulating Smad expression, activation, and nuclear translocation
Townsend et al., Cells Tissues Organs 2011 : Targeting of Smad4, the common mediator Smad, demonstrated that Smad signaling is required for EMT in the AVC and TGFßR3 dependent EMT stimulated by TGFß2 or BMP-2
Park et al., Cancer Sci 2011 (Cell Transformation, Neoplastic...) : The novel ALK5 inhibitor, EW-7203, efficiently inhibited TGF-ß1 induced Smad signalling, EMT and breast tumor metastasis to the lung in vivo, demonstrating that EW-7203 has therapeutic potential for breast cancer metastasis to the lung
Ai et al., J Natl Cancer Inst 2011 (Adenocarcinoma...) : Furthermore, high expression of pIgR was sufficient to induce EMT through activation of Smad signaling