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IL2 — SMAD7

Text-mined interactions from Literome

Tzachanis et al., Nat Immunol 2001 : The inhibitory effect of Tob on interleukin 2 (IL-2) transcription was not mediated by blockade of NFAT, AP-1 or NF-kappaB transactivation but by enhancement of Smad binding on the -105 negative regulatory element of the IL-2 promoter
Verrecchia et al., J Biol Chem 2003 : We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ), interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not inhibit the formation of SMAD-DNA complexes and the resulting SMAD-driven transcription in response to TGF-beta
Yoshioka et al., Eur J Immunol 2012 : Dorsomorphin efficiently suppressed IL-2 production even at low doses in mouse CD4 ( + ) T cells, suggesting that the BMP-Smad signalling physiologically regulates IL-2 transcription in these cells
Verma et al., J Biol Chem 2012 : Increased expression of SMAD7 and SMURF2 in LFA-1/ICAM-1 cross linked T-cells resulted in impaired TGF-ß mediated phosphorylation of SMAD2 and suppression of IL-2 secretion
Meisel et al., Immunity 2013 (Encephalomyelitis, Autoimmune, Experimental) : Furthermore, PKCa-deficient ( Prkca ( -/- ) ) cells demonstrated a defect in SMAD dependent IL-2 suppression, as well as decreased STAT3 DNA binding within the Il17a promoter