Gene interactions and pathways from curated databases and text-mining

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SNAI2 — WNT6

Text-mined interactions from Literome

Katoh et al., Curr Pharm Biotechnol 2011 : Because FGF, Hedgehog, TGFß, and non-canonical WNT signals synergistically induce EMT regulators, such as Snail ( SNAI1 ), Slug ( SNAI2 ), TWIST, and ZEB2 ( SIP1 ), tumor-stromal interaction at the invasion front aids cancer stem cells to acquire more malignant phenotype
Subramaniam et al., Arch Pathol Lab Med 2011 (Sarcoma, Synovial) : In monophasic fibrous tumors, increased expression of Snail ( 17 of 27 ; 63 % ), Slug ( 18 of 27 ; 67 % ), and dysadherin ( 14 of 27 ; 52 % ) and activation of Wnt ( nucleocytoplasmic ß-catenin accumulation in 63 % ; n = 27 ; and positive expression of GSK3 and pGSK3 in 24 of 27 [ 89 % ] and 21 of 27 [ 78 % ], respectively ) and PI3K/Akt ( Akt : 22 of 27 [ 81 % ] ; pAkt : 25 of 27 [ 93 % ] ; and PI3K : 20 of 27 [ 74 % ] ) signaling correlated significantly with inactivated E-cadherin expression ( 1 of 27 ; 4 % )
Wu et al., Proc Natl Acad Sci U S A 2012 (Breast Neoplasms...) : Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset ( BRCA1 ) repression ... Alternatively, in the presence of canonical Wnt ligands, GSK3ß kinase activity is inhibited, nuclear Slug levels increase, and EMT programs are initiated