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AKT1 — SOCS1
Text-mined interactions from Literome
Mooney et al., J Biol Chem 2001
(Insulin Resistance) :
SOCS-1 and SOCS-6 do not inhibit insulin dependent IR autophosphorylation, but both proteins
inhibit insulin dependent activation of ERK1/2 and
protein kinase B in vivo and IR-directed phosphorylation of IRS-1 in vitro
Inaba et al., Biochem Biophys Res Commun 2005
:
Additionally,
SOCS1 augmented MEK phosphorylation and reduced
Akt phosphorylation induced by IGF-I
Emberley et al., Cancer Res 2005
(Breast Neoplasms) :
Structural analysis by three-dimensional protein modeling, immunoprecipitation, and yeast two-hybrid assay and functional analysis using transfected reporter gene and Western blot assays revealed that the in vitro effects of S100A7 on
phospho-Akt and the nuclear factor-kappaB pathway are
dependent on the Jab1 binding site and the interaction with
Jab1
Tortorella et al., J Gerontol A Biol Sci Med Sci 2006
:
These results indicate that defective
PI3-K/Akt/ERK1/2 activation, likely
dependent on elevated
SOCS1 and SOCS3 levels, may affect the GM-CSF capacity to delay neutrophil apoptosis in elderly persons
Venieratos et al., Cell Signal 2010
:
Inhibition of
SOCS-1 expression by SOCS-1-specific small interfering RNA
restored IRS-2/PI3K mediated
Akt phosphorylation suppressed by high glucose