UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

KEGG Jak-STAT signaling pathway: SOCS1/SOCS2/SOCS3/SOCS4/SOCS5/SOCS7 → CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR (protein-protein, inhibition)
NCI Pathway Database IL12-mediated signaling events: SOCS1 (SOCS1) → IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1) (modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
NCI Pathway Database IL12-mediated signaling events: SOCS1 (SOCS1) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction