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RAC1 — SOD1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: RAC1 — SOD1 (direct interaction, pull down) Harraz et al., J Clin Invest 2008*

Text-mined interactions from Literome

Li et al., J Biol Chem 2011 (Amyotrophic Lateral Sclerosis...) : Our studies demonstrate that glial cell expression of SOD1 ( G93A ) or wild type alsin induces ROS production, Rac1 activation, secretion of TNFa, and activation of NF?B, leading to decreased motor neuron survival in co-culture ... SOD1 ( G93A ) expression dramatically enhanced TNFa mediated endosomal ROS in glial cells in a Rac1 dependent manner and alsin overexpression inhibited SOD1 ( G93A ) -induced endosomal ROS and Rac1 activation
Aoyama et al., Hepatology 2012 (Liver Cirrhosis) : Conclusions : SOD1mu induces excessive NOX1 activation through Rac1 in HSCs, causing enhanced NOX4 up-regulation, ROS generation, and liver fibrosis