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NOS2 — SOD3

Text-mined interactions from Literome

Frank et al., FASEB J 1999 (Endotoxemia) : In these animals, we demonstrate a direct coupling of Cu/Zn SOD expression levels to the presence of NO, as Cu/Zn SOD mRNA levels declined during acute inflammation in the presence of a selective inhibitor of iNOS
Mehta et al., J Mol Cell Cardiol 2000 (Reperfusion Injury) : AS-ODNs, but not IN-ODNs, protected hearts against functional deterioration, and upregulated SOD expression and inhibited the expression of iNOS
Saito et al., Stroke 2001 (Subarachnoid Hemorrhage...) : The inhibitory effect of CuZn-superoxide dismutase ( CuZn-SOD ) on the induction of iNOS after SAH was examined by using transgenic mice overexpressing CuZn-SOD
Mizoguchi et al., J Gastroenterol Hepatol 2001 (Intestinal Diseases) : The protection by rebamipide was accompanied by a significant suppression of the increase in both MPO and iNOS activities, and a complete inhibition of the increase in TBA reactants, while SOD + CAT significantly inhibited the increase of MPO activity and TBA reactants, but not iNOS activity
Kim et al., Carcinogenesis 2003 : Similarly, co-culture of AS52 cells with LPS/IFN-gamma stimulated RAW 264.7 cells also increased the mutation frequency of the gpt gene by 2.6-fold, and this increase in mutation frequency was suppressed by SOD , DPI and N ( 5 ) - ( 1-iminoethyl ) -L-ornithine dihydrochloride ( L-NIO ), an specific iNOS inhibitor ( IRs = 58.3, 70.8 and 70.8 %, respectively )
Polytarchou et al., Free radical research 2004 : Superoxide dismutase ( SOD ) and its membrane permeable mimetic tempol, dose dependently decreased angiogenesis and down-regulated inducible nitric oxide synthase (iNOS) expression and nitric oxide ( NO ) production
Jifa et al., Ecotoxicol Environ Saf 2006 : The results indicated that ( 1 ) L. japonicus avoided oxidative damage through antioxidant systems ; ( 2 ) SOD , GPx, and GSH were induced, and GST was inhibited and then induced by B [ a ] P exposure ; and ( 3 ) CAT, GPx, and AChE were induced while iNOS was inhibited, and GST was induced and then inhibited by SDBS stress in experimental period
Hu et al., J Ethnopharmacol 2008 (Drug-Induced Liver Injury) : Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content, but not superoxide dismutase ( SOD ) activity, and it inhibited the CCl ( 4 ) -induced high expression of iNOS and TNF-alpha in hepatic tissue
Lee et al., Exp Mol Med 2009 : Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells ... These data suggest that SOD differentially regulate expression of iNOS and COX-2 in LPS stimulated RAW 264.7 cells
Berman et al., Br J Pharmacol 1993 : 3. The increase in albumin transfer induced by hypoxanthine and xanthine oxidase was abolished by catalase ( 3 u ml-1 ), reduced by allopurinol ( 4 mM ), but unaffected by superoxide dismutase ( 6000 u ml-1 ), the hydroxyl radical scavengers, mannitol ( 15 mM ), dimethylthiourea ( 10 mM ) and N- ( 2-mercaptopropionyl ) -glycine ( 1 mM ), the iron chelator, deferoxamine ( 0.5 mM ), ferric chloride ( 50 microM ), an inhibitor of nitric oxide synthase , NG-nitro-L-arginine ( 30 microM ), or the antioxidant, dithiothreitol ( 3 mM )
Allen et al., J Infect Dis 1997 : The possibility that peroxynitrite contributes to this maximum luminol dependent activity was tested, but neither superoxide dismutase , a competitive inhibitor of peroxynitrite production, nor N-methyl-L-arginine, an inhibitor of nitric oxide synthase , exerted a significant inhibitory effect
Sugaya et al., Neuroreport 1997 : The i-NOS inhibitor L-N6- ( 1-iminoethyl ) -lysine ( NIL, 600 microM ) suppressed the nitrite accumulation and the increase in Mn-SOD-like immunoreactivity in activated cells without significant effect on the level of i-NOS-like immunoreactivity
Nelson et al., Hum Reprod 1998 : In both P and NP arteries the cholinergic relaxation was increased in the presence of superoxide dismutase and greatly reduced in the presence of the nitric oxide synthase inhibitors, NG-mono-methyl L-arginine ( L-NMMA ) and L-nitro-arginine-methylester ( L-NAME )