Gene interactions and pathways from curated databases and text-mining

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NOTCH3 — SOX2

Text-mined interactions from Literome

Dabdoub et al., Proc Natl Acad Sci U S A 2008 : Sox2 expression is promoted by Notch signaling and Prox1, a homeobox transcription factor, is a downstream target of Sox2
Genethliou et al., Biochem Biophys Res Commun 2009 : We show that, SOX1 expression in the vSC is regulated by PAX6, NKX2.2 and Notch signalling in a domain-specific manner
Ehm et al., J Neurosci 2010 : Interestingly, we found that Notch signaling increases Sox2 promoter activity and Sox2 expression in adult neural stem cells
Zakharova et al., PloS one 2012 : In c-Kit+ cells, Notch stimulation reduced, while Notch inhibition up-regulated pluripotency marker expressions such as Nanog and Sox2
Matsuda et al., J Neurosci 2012 : The High Mobility Group ( HMG ) -box transcription factor, Sox2 , and the cell surface activated transcriptional regulator, Notch , play important roles in CNS stem cells