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SP1 — STAT3

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → STAT3 (transcriptional regulation, unknown)
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT3 — SP1 (physical association, affinity chromatography technology) Proietti et al., Steroids 2011*
• IRef Biogrid Interaction: STAT3 — SP1 (physical association, affinity chromatography technology) Lin et al., Mol Endocrinol 2006*
• IRef Biogrid Interaction: STAT3 — SP1 (physical association, affinity chromatography technology) Zhang et al., J Cell Biochem 2007
• IRef Intact Interaction: Complex of SP1-PGR-STAT3 (association, anti bait coimmunoprecipitation) Proietti et al., Steroids 2011*

Text-mined interactions from Literome

Loeffler et al., Int J Cancer 2005 (Glioblastoma) : Interestingly, preincubation with STAT3 antibody prevented the binding of Sp1 and Sp3 to the -88/-50 element, indicating that STAT3 is involved in IL-6-driven Sp1/Sp3 protein-DNA complex formation
Tapias et al., Cell cycle (Georgetown, Tex.) 2008 : Among the known Sp1 interacting proteins, E2F-DP1, Cyclin D1, Stat3 and Rb activated the Sp1 promoter, whereas p53 and NF kappaB inhibited it
Su et al., Am J Physiol Cell Physiol 2009 : Cell confluency induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation ... Thus, during confluency, ligand independent Stat3 activation leads to its interaction with Sp1/Sp3 , their recruitment to the SpA/B/C cluster in a Stat3 DNA binding domain dependent fashion, increased transcription, and expression of NHE3, to coordinate cell density mediated epithelial dome formation