Gene interactions and pathways from curated databases and text-mining

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INS — STK31

Text-mined interactions from Literome

Li et al., J Biol Chem 1999 : In addition, the PDGF activated serine/threonine kinase called Akt was found to inhibit insulin signaling
Tartare et al., J Biol Chem 1991 : These results suggest that insulin-EGF chimeric receptor activation stimulates at least one serine/threonine kinase , which in turn phosphorylates the kinase-deficient EGF receptor
Izumi et al., J Biol Chem 1991 : We have examined the phosphorylation of the serine threonine kinase , the product of c-raf proto-oncogene in response to insulin or platelet derived growth factor in intact cells
Shaw et al., Cell Metab 2008 (Muscular Dystrophies) : The mammalian target of rapamycin (mTOR) serine/threonine kinase plays a central role in insulin signaling and cell growth, through two distinct complexes with its subunits raptor or rictor
Amato et al., J Mol Med (Berl) 2009 : Serum and glucocorticoid regulated kinase 1 ( Sgk1 ) is a serine-threonine kinase that is activated by serum, steroids, insulin , vasopressin, and interleukin 2 at the transcriptional and post-translational levels
Bergeron et al., Endocrinology 2011 : Expression of DNSHP-1 increased insulin induced Akt serine-threonine kinase phosphorylation and augmented glucose uptake and glycogen synthesis
Kovacina et al., J Biol Chem 1990 : These findings indicate that insulin activates the serine/threonine kinase activity of the Raf-1 proto-oncogene by increasing its content of phosphoserine
Yuzefovych et al., Endocrinology 2012 : Protection of mtDNA from palmitate induced damage by overexpression of hOGG1 targeted to mitochondria significantly diminished palmitate induced mitochondrial superoxide production, restored the decline in ATP levels, reduced activation of c-Jun N-terminal kinase (JNK) kinase, prevented cells from entering apoptosis, increased insulin stimulated phosphorylation of serine-threonine kinase ( Akt ) ( Ser473 ) and tyrosine phosphorylation of insulin receptor substrate-1, and thereby enhanced glucose transporter 4 translocation to plasma membrane, and restored insulin signaling
Filho et al., Eur J Pharmacol 2013 (Hypertrophy, Left Ventricular...) : Insulin induced vasorelaxation due to endothelial nitric oxide synthase (eNOS) activation is highly dependent on the activation of the upstream insulin stimulated serine/threonine kinase ( AKT ) and is severely impaired in obese, hypertensive rodents and humans
Yu et al., Proc Natl Acad Sci U S A 1987 : The insulin stimulated serine/threonine kinase exhibits preferential phosphorylation of histone and Kemptide ( synthetic Leu-Arg-Arg-Ala-Ser-Leu-Gly ) compared to a number of other peptide substrates ... The data suggest that this insulin stimulated serine/threonine kinase in adipocyte high-density microsomes is tyrosine phosphorylated, consistent with the hypothesis that the stimulatory action of insulin on this kinase may be mediated by tyrosine phosphorylation
Silliman et al., Biochem Biophys Res Commun 1989 : Chymotryptic digestion was used to localize the sites in microtubule associated protein 2 which are preferentially phosphorylated in vitro by MAP kinase, an insulin stimulated serine/threonine kinase which efficiently utilizes high molecular weight MAPs as substrates
Rossomando et al., Proc Natl Acad Sci U S A 1989 : Stimulation of 3T3-L1 cells with insulin has been shown to activate a cytosolic serine/threonine kinase capable of phosphorylating microtubule associated protein 2 (MAP-2) and ribosomal protein S6 kinase II
Brownsey et al., Biochem Cell Biol 1988 : A range of assay conditions was employed to characterize the insulin stimulated protein serine ( threonine ) kinase in in supernatant fractions ... The insulin stimulated protein serine ( threonine ) kinase displays properties that indicate it is distinct from a number of well characterized protein kinases, including those regulated by cAMP, calcium ions ( in the presence or absence of calmodulin or mixtures of phosphatidylserine-diacylglycerol ), polyamines, or heparin
Ray et al., Proc Natl Acad Sci U S A 1987 : These results show that a soluble serine/threonine kinase is rapidly activated by insulin , possibly by phosphorylation of either the kinase itself or an interacting modulator
Brozinick et al., J Biol Chem 1998 : In the present study, we have examined the role of Akt, an insulin activated serine threonine kinase that has previously been shown to increase glucose transport in adipocytes