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CA2 — SYT1

Text-mined interactions from Literome

Leveque et al., J Neurochem 2000 : Our findings are consistent with models in which the Ca2+ triggered release of synaptotagmin precedes vesicle fusion
Honda et al., J Biol Chem 2002 : Direct, Ca2+ dependent interaction between tubulin and synaptotagmin I : a possible mechanism for attaching synaptic vesicles to microtubules
Chieregatti et al., Traffic 2002 : These results show that Ca2+ modulates dynamic docking of granules to the plasma membrane and that this process is due to a Ca2+ dependent interaction between SNAP-25 and Synaptotagmin 1
Zhang et al., Neuron 2002 (Calcium Signaling...) : Ca2+ dependent synaptotagmin binding to SNAP-25 is essential for Ca2+ triggered exocytosis ... We found that synaptotagmins I and IX associate with SNAP-25 during Ca2+ dependent exocytosis in PC12 cells, and we identified C-terminal amino acids in SNAP-25 ( Asp179, Asp186, Asp193 ) that are required for Ca2+ dependent synaptotagmin binding ... These results indicate that the Ca2+ dependent interaction of synaptotagmin with SNAP-25 is essential for the Ca2+ dependent triggering of membrane fusion
Lawrence et al., J Cell Sci 2002 (Calcium Signaling) : Ca2+ induced changes in SNAREs and synaptotagmin I correlate with triggered exocytosis from chromaffin cells : insights gleaned into the signal transduction using trypsin and botulinum toxins
Araç et al., Biochemistry 2003 : A study showing that phospholipids compete with the neuronal core complex for Ca2+ dependent binding to the presynaptic Ca2+-sensor synaptotagmin 1 illustrates the usefulness of the SMRC method in studying multicomponent systems
Jo et al., Yonsei Med J 2006 : We investigated a type of Ca2+ dependent synaptotagmin and Ca2+ signaling in both rat and mouse parotid acinar cells using RT-PCR, microfluorometry, and amylase assay
Pang et al., J Neurosci 2006 : Using knock-in mice that carry aspartate-to-asparagine substitutions in a Ca2+ binding site of synaptotagmin-1 ( the D232N or D238N substitutions ), we now show that the D232N mutation dramatically increases Ca2+ dependent SNARE complex binding by native synaptotagmin-1 , but leaves phospholipid binding unchanged ... These data establish that fast vesicle exocytosis is driven by a dual Ca2+ dependent activity of synaptotagmin-1 , namely Ca2+ dependent binding both to SNARE complexes and to phospholipids
Lopez et al., FASEB J 2007 : Previous studies indicate that the process requires Rab3 dependent tethering of membranes, SNARE complex assembly, and Ca2+ mediated activation of synaptotagmin
Yoon et al., Mol Pharmacol 2007 : Gbetagamma interferes with Ca2+ dependent binding of synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor ( SNARE) complex
Stein et al., Nature structural & molecular biology 2007 : Ca2+ dependent binding of synaptotagmin to its own membrane impedes the activation
Chapman et al., J Biol Chem 1995 : Ca2+ regulates the interaction between synaptotagmin and syntaxin 1
Takamori et al., Ann Neurol 1994 (Disease Models, Animal...) : Findings are similar to those in human Lambert-Eaton myasthenic syndrome and passively transferred Lambert-Eaton myasthenic syndrome in mice, and thus suggest that antibody to a synaptotagmin-voltage dependent Ca2+ channel complex may be involved in the pathogenesis of Lambert-Eaton myasthenic syndrome
Kim et al., Proc Natl Acad Sci U S A 1997 : Binding of synaptotagmin to the rbA isoform of alpha1A is Ca2+ dependent , with maximum affinity at 10-20 microM Ca2+