Gene interactions and pathways from curated databases and text-mining

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CREB5 — TAT

Text-mined interactions from Literome

Zauli et al., FASEB J 2001 : Moreover, in transient transfection experiments, Tat inhibited transcription of CREB promoter in a manner strictly dependent on the presence of the cAMP-responsive elements ( CRE ) in the CREB promoter
Lee et al., Cardiovasc Res 2004 : However, Tat did not affect DNA binding activities of AP-1, CREB , and STAT1
Williams et al., Experimental biology and medicine (Maywood, N.J.) 2005 (HIV Infections) : Within 2 hrs after stimulation, Tat increased both CREB phosphorylation and DNA binding by 7- to 10-fold
Zhong et al., J Neurosci 2012 : Interestingly, inhibition of the Rho cascade protected against Tat induced upregulation of ZO-1 in the nuclei and activation of CREB
Bell et al., J Neurochem 2013 (Anoxia...) : Tat-NR2B9c dependent neuroprotection and CREB phosphorylation are blocked by coapplication of CaM kinase ( KN93 and STO-609 ) or CREB ( KG-501 ) inhibitors, and by siRNA knockdown of CaMKIV
Gibellini et al., J Immunol 1998 : Moreover, the use of plasmids encoding for GAL4-CREB fusion proteins demonstrated that Tat induction of pG4-CAT reporter gene required the CREB moiety of the GAL4-CREB fusion protein and that Ser133 CREB was essential for Tat activity ... Extracellular Tat also stimulated Ser133 CREB phosphorylation in freshly isolated PBMC ; this effect was completely blocked by either staurosporin, a broad-spectrum inhibitor of various protein kinases, or PD 98059, a specific inhibitor of mitogen activated protein kinases ( MAPK )