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NOTCH1 — TCF20
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Berezovska et al., Neuroscience 1999
:
We also examined whether
Notch1 could
activate C-promoter binding factor ( CBF1 )
transcription factor using C-promoter binding factor-luciferase constructs, and demonstrated that this signal transduction pathway is present and can be activated in postmitotic neurons
Robert-Moreno et al., Development 2005
:
Since
Notch requires binding to RBPjkappa
transcription factor to activate transcription, we analyzed the aorta of the para-aortic splanchnopleura/AGM in RBPjkappa mutant embryos
Reschly et al., Blood 2006
(Cell Transformation, Neoplastic...) :
Loss of E2A
transcription factor activity or
activation of the intracellular form of
Notch1 ( ICN ) leads to the development of leukemia or lymphoma in humans or mice, respectively
Kinameri et al., PloS one 2008
:
An evolutionary conserved program consisting of
Notch signalling
mediated by basic Helix-Loop-Helix ( bHLH )
transcription factor activity is necessary for both the maintenance of neural progenitor cell character and the progression of neurogenesis ; however, additional players in mammalian CNS neural specification remain largely unknown
Lee et al., Mol Cancer Res 2009
:
Activation of SRC/STAT3 pathway by
Notch signaling was
dependent on the expression of Notch effector HES1
transcription factor
Brimer et al., Oncogene 2012
:
BPV-1 induced papillomas show characteristics of repressed NOTCH signal transduction, including suprabasal expression of integrins, talin and basal type keratins, and delayed expression of the
NOTCH dependent HES1
transcription factor
Matsuda et al., J Neurosci 2012
:
The High Mobility Group ( HMG ) -box
transcription factor , Sox2, and the cell surface
activated transcriptional regulator,
Notch , play important roles in CNS stem cells
Chen et al., PloS one 2012
:
We further showed that, by using a conditional knockout model of RBP-J ( the critical
transcription factor mediating
Notch signaling ), Notch signaling differentially regulates EEPCs and EOCs