Gene interactions and pathways from curated databases and text-mining

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EPHB2 — TERF1

Text-mined interactions from Literome

Mochizuki et al., Nature 1999 : This decrease in GTP bound Rap1 activates ERK/MAPK
Pizon et al., Oncogene 2000 (MAP Kinase Signaling System) : We provide evidence that Rap1A mutants promote ERK activation and that the active protein induces a more sustained activation than the inactive protein
Sawada et al., J Cell Sci 2001 (MAP Kinase Signaling System) : Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase ... Furthermore, overexpression of Rap1 enhanced p38 activity but not ERK or JNK activity
Garcia et al., Mol Cell Biol 2001 : We show that the small GTPases Ras and Rap1 contribute together to TPO induced ERK activation in UT7-Mpl cells and that they do so by activating different Raf kinases as downstream effectors : a Ras-Raf-1 pathway is required to initiate ERK activation while Rap1 sustains this signal through B-Raf ... Indeed, ( i ) in cells expressing wild-type or mutant Mpl, TPO induced Ras and Rap1 activation correlates with early and sustained phases of ERK signal, respectively ; ( ii ) interfering mutants of Ras and Rap1 both inhibit ERK kinase activity and ERK dependent Elk1 transcriptional activation in response to TPO ; ( iii ) the kinetics of activation of Raf-1 and B-Raf by TPO follow those of Ras and Rap1, respectively ; ( iv ) RasV12 mediated Elk1 activation was modulated by the wild type or interfering mutants of Raf-1 but not those of B-Raf ; ( v ) Elk1 activation mediated by a constitutively active mutant of Rap1 ( Rap1V12 ) is potentiated by B-Raf and inhibited by an interfering mutant of this kinase
Schmitt et al., Mol Cell Biol 2001 : In NIH 3T3 cells, Rap1 is required not only for cAMP 's inhibition of ERK activation but for inhibition of cell proliferation and mitogenesis as well
Wang et al., J Biol Chem 2001 : Moreover, inhibition of Rap1 by a Rap1 GTPase activating protein-1 also resulted in a decrease in ERK and Akt phosphorylation, which was not further decreased by cAMP, suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 ... The role of Rap1 in ERK and Akt activity was further demonstrated by our observation that an active form of Epac, which activated Rap1 in the absence of cAMP, increased ERK and Akt phosphorylation
Iacovelli et al., Mol Pharmacol 2001 : The Rap1 dominant negative Rap1N17 significantly reduced TSH stimulated but not insulin-like growth factor 1-stimulated ERK1/2 phosphorylation, whereas the Ras dominant negative RasN17 inhibited the effect of both agonists
Fujita et al., J Biol Chem 2002 : cAMP stimulated Ras independent and Rap1 dependent ERK phosphorylation and cell proliferation in B-Raf expressing cells, but inhibited growth in B-Raf lacking cells
Grader-Beck et al., Blood 2003 : Thus, TCR plus CD28 mediated activation of ERK1/2 and PKB, cytokine production, and cell cycle progression, all of which are inhibited by cAMP, require activation of Ras but not Rap1
Enserink et al., Nat Cell Biol 2002 : We conclude that cAMP induced regulation of ERK and activation of Rap1 are independent processes
Schulte et al., Exp Cell Res 2003 : Inhibition of phosphatidylinositol-3'-kinase (PI3K) by wortmannin inhibited adenosine A(2B) receptor mediated ERK1/2 phosphorylation and activation of Rap1 , without affecting CREB and p38 phosphorylation
Romano et al., J Biol Chem 2003 : Experiments involving the expression of the dominant negative mutants of Ras and Rap1 signaling ( RasN17 or Rap1N17 ) indicate that both GTPases Ras and Rap1 are recruited for the ERK activation by VIP and PACAP38, whereas Rap1 is poorly involved in TRH or EGF induced ERK activation
Arévalo et al., EMBO J 2004 : ARMS is rapidly tyrosine phosphorylated after binding of neurotrophins to Trk receptors and provides a docking site for the CrkL-C3G complex, resulting in Rap1 dependent sustained ERK activation
Calipel et al., J Biol Chem 2006 (Cell Transformation, Neoplastic...) : This ruled out a role for Rap1 in the PKA mediated B-Raf/ERK activation in ( WT ) B-Raf cells
Wang et al., Mol Cell Biol 2006 : We confirm that the PKA independent activation of Rap1 by Epac1 activates a perinuclear pool of Rap1 and that this does not result in ERK activation
Wang et al., J Biol Chem 2006 : Our data indicate that activation of Rap1 or MEKK2 is sufficient to stimulate ERK5, whereas inhibition of either Rap1 or MEKK2 attenuates BDNF activation of ERK5
Kogut et al., Mol Immunol 2007 : Rap1 has been shown to activate the ERK1/2 via a different Raf family member B-Raf whose downstream effector is MEK1/2
Xie et al., Mol Pharmacol 2007 (MAP Kinase Signaling System...) : Furthermore, PKA dependent Rap1 activation is required for both ERK1/2 activation and androgen independent AR activation in LNCaP cells upon VIP stimulation
Wakamatsu et al., J Biol Chem 2007 : Moreover, Ca2+ induced activation of ERK through Rap1 and expression of loricrin were reduced in primary cultured nectin-1-/- keratinocytes ; in turn, the inhibition of ERK activation reduced the amount of loricrin in wild-type keratinocytes
Pertuit et al., Endocrinology 2011 : In this study on the conditional gsp-oncogene expressing GH4C1 cell line, expression of the gsp oncogene, which was observed in up to 40 % of GH-secreting adenomas, was found to induce sustained ERK1/2 activation, which required activation of the protein kinase A and the GTPases Ras and Rap1