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TFAP2A — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Alaaeddine et al., Arthritis Rheum 1999
(Osteoarthritis) :
AP-2 and CREB were not
induced by
TNFalpha
Nyormoi et al., Mol Cell Biol 2001
(Breast Neoplasms) :
We tested this hypothesis by examining the
effects of
tumor necrosis factor alpha (TNF-alpha) on the expression of
AP-2 in breast cancer cells ...
TNF-alpha induced cleavage of
AP-2alpha in vivo led to AP-2alpha degradation and loss of DNA binding activity, both of which were prevented by pretreatment with zVEIDfmk
Gustafson et al., Biochem Biophys Res Commun 2003
:
Several observations showed that the adiponectin and aP2 genes can be differentially regulated in adipocytes : ( 1 ) Topiramate, an anti-epileptic agent with weight reducing properties, increased adiponectin mRNA levels and secretion, but did not, like the thiazolidinediones, increase aP2 expression ; ( 2 ) IL-6 reduced adiponectin, but significantly increased, aP2 expression ; and ( 3 )
TNFalpha inhibited adiponectin, but paradoxically increased,
aP2 expression in PPAR gamma 2-infected C/EBP alpha null cells
Zhang et al., Mol Endocrinol 1996
:
Low level constitutive expression of PPAR gamma in 3T3-L1 adipocytes ( at levels approximately 2- to 3-fold higher than in preadipocytes ) partially blocked the inhibitory
effect of
TNF alpha on
aP2 and adipsin expression