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GJA1 — TGFB1
Text-mined interactions from Literome
Larson et al., Endothelium : journal of endothelial cell research 2001
:
TGF-beta1 induces an accumulation of
connexin43 in a lysosomal compartment in endothelial cells ... As part of these studies, we examined the
effect of the growth inhibitory cytokine
TGF-beta1 on
Cx43 expression
Rama et al., Eur J Cell Biol 2006
:
Here, we set out to examine the
effects of
TGF-beta1 on
Cx43-gap junction expression in relation to SMC differentiation, ECM synthesis and growth
Tacheau et al., J Cell Physiol 2008
:
Herein, we demonstrated that
TGF-beta1 induces the expression of
connexin43 (Cx43) in normal murine mammary gland ( NMuMG ) cell lines at the protein and mRNA levels, and transcriptionally ... In addition, using overexpression of truncated dominant negative forms of either Smad2 or Smad3, and MDA-MB-468 human breast carcinoma cells deficient for Smad4, we determined that the Smad cascade is not implicated in
TGF-beta1 effect on
Cx43 expression ... Using specific pharmacologic inhibitors for JNK, ERK, p38, and PI3K/AKT signaling pathways, we demonstrated the cooperative role of p38 and PI3K/AKT signaling in
TGF-beta1 induced
Cx43 expression and gap junctional communication ... Furthermore, transfection of a c-jun antisense expression vector significantly prevented TGF-beta1 induced Cx43 gene expression demonstrating the involvement of c-Jun/AP-1 pathway together with p38 and PI3K/AKT pathways in mediating
TGF-beta1 induced
Cx43 gene expression
Hills et al., Cell Physiol Biochem 2009
(Cell Transformation, Viral) :
The
effect of
TGF-beta1 and high glucose ( 25 mM ) on
Cx43 protein expression, cytoskeletal organisation and cell-cell communication was determined in the presence/absence of TGF-beta1 specific immuno neutralising antibodies ... High glucose evoked a
TGF-beta1 mediated increase in
Cx43 expression and gap-junction mediated cell-cell communication in HCD-cells
Heinrich et al., PloS one 2011
(Urinary Bladder, Overactive) :
Therefore, we investigate the
effect of interleukin (IL) 4, IL6, IL10, tumor necrosis factor-alpha ( TNFa ) and
transforming growth factor-beta1 ( TGFß1 ) on GJIC, and
Cx43 and Cx45 expression in cultured human bladder smooth muscle cells ( hBSMC ) and human suburothelial myofibroblasts ( hsMF )
Xie et al., Cell communication and signaling : CCS 2013
:
Furthermore, overexpression of
Cx43 or inhibition of c-Src
attenuated the upregulation of intercellular adhesion molecule-1 ( ICAM-1 ),
transforming growth factor-beta 1 ( TGF-ß1 ) and fibronectin ( FN ) expression induced by high glucose
Larson et al., Am J Physiol 1997
:
Differential
regulation of
connexin43 and connexin37 in endothelial cells by cell density, growth, and
TGF-beta1