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JAK2 — THPO
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Moore et al., Blood 2013
(Thrombocythemia, Essential) :
In addition,
thrombopoietin mediated
JAK2 phosphorylation was unchanged, suggesting that signaling pathways activated downstream of JAK2 are impaired
Ezumi et al., FEBS Lett 1995
:
Thrombopoietin , c-Mpl ligand,
induces tyrosine phosphorylation of Tyk2,
JAK2 , and STAT3, and enhances agonists induced aggregation in platelets in vitro
Tortolani et al., Blood 1995
(Leukemia) :
Thrombopoietin induces tyrosine phosphorylation and activation of the
Janus kinase , JAK2
Miyakawa et al., Blood 1995
:
Recombinant
thrombopoietin induces rapid protein tyrosine phosphorylation of
Janus kinase 2 and Shc in human blood platelets
Miyakawa et al., Blood 1996
:
Recently, we and others have shown that
thrombopoietin induces rapid tyrosine phosphorylation of
Jak2 and other proteins in human platelets and BaF3 cells, genetically engineered to express c-Mpl, a receptor for thrombopoietin
Oda et al., Blood 1996
:
To investigate the signaling processes induced by recombinant thrombopoietin, we used human platelets to recently show that
thrombopoietin induces rapid tyrosine phosphorylation of
Jak2 , Tyk2, Shc, Stat3, Stat5, and other proteins in human platelets
Miyakawa et al., Blood 1997
:
To investigate the signaling processes induced by thrombopoietin, we have employed human platelets and recently demonstrated that
thrombopoietin induces rapid tyrosine phosphorylation of
Jak-2 , Tyk2, Shc, Stat3, Stat5, p120 ( c-cbl ) and other proteins in human platelets
Sattler et al., J Cell Physiol 1997
:
We have previously shown that activation of c-MPL by
thrombopoietin rapidly
activates at least two cytoplasmic tyrosine kinases,
JAK2 and TYK2, after ligand binding