Gene interactions and pathways from curated databases and text-mining

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JAK2 — THPO

Pathways - manually collected, often from reviews:

  • BioCarta tpo signaling pathway: TPO/TPO/TPO R/TPO R complex (THPO-MPL) → JAK2 (modification, activates)

Text-mined interactions from Literome

Moore et al., Blood 2013 (Thrombocythemia, Essential) : In addition, thrombopoietin mediated JAK2 phosphorylation was unchanged, suggesting that signaling pathways activated downstream of JAK2 are impaired
Ezumi et al., FEBS Lett 1995 : Thrombopoietin , c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2 , and STAT3, and enhances agonists induced aggregation in platelets in vitro
Tortolani et al., Blood 1995 (Leukemia) : Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase , JAK2
Miyakawa et al., Blood 1995 : Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets
Miyakawa et al., Blood 1996 : Recently, we and others have shown that thrombopoietin induces rapid tyrosine phosphorylation of Jak2 and other proteins in human platelets and BaF3 cells, genetically engineered to express c-Mpl, a receptor for thrombopoietin
Oda et al., Blood 1996 : To investigate the signaling processes induced by recombinant thrombopoietin, we used human platelets to recently show that thrombopoietin induces rapid tyrosine phosphorylation of Jak2 , Tyk2, Shc, Stat3, Stat5, and other proteins in human platelets
Miyakawa et al., Blood 1997 : To investigate the signaling processes induced by thrombopoietin, we have employed human platelets and recently demonstrated that thrombopoietin induces rapid tyrosine phosphorylation of Jak-2 , Tyk2, Shc, Stat3, Stat5, p120 ( c-cbl ) and other proteins in human platelets
Sattler et al., J Cell Physiol 1997 : We have previously shown that activation of c-MPL by thrombopoietin rapidly activates at least two cytoplasmic tyrosine kinases, JAK2 and TYK2, after ligand binding