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FGF2 — TIMP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TIMP1 → FGF2 (increases)
  Evidence: Stimulation of endothelial cells by FGF2 causes also the shedding of cell surface membrane vesicles containing MMP-2 and MMP-9 together with the two MMP inhibitors TIMP-1 and TIMP-2. These vesicles stimulate capillary-like structure formation when added to endothelial cells seeded on a solubilized basement membrane preparation (Matrigel) [26].
• OpenBEL Selventa BEL large corpus: TIMP1 → FGF2 (increases)
  Evidence: FGF2 [50] and FGF8b [17] can enhance endothelial cell reorganization onMatrigel.The process requires the activation of the proteolytic machinery, including type IV collagenase(s) and TIMPs production [51] as well as uPA and PAI-1 upregulation [52], a6b1 integrin receptor engagement [53], PECAM-1 [54], and activation of the small GTPase Rac [55].

Text-mined interactions from Literome

Bigg et al., Eur J Biochem 2000 : The tyrosine kinase inhibitor genistein caused a dose dependent inhibition of TIMP-1 protein induction by ATRA and bFGF
Toschi et al., Mol Biol Cell 2001 (Acquired Immunodeficiency Syndrome...) : These effects are due to the activation of the membrane-type-1-matrix-metalloproteinase and to the induction of the membrane bound tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) by Tat and bFGF combined, but also to Tat mediated inhibition of both basal or bFGF induced TIMP-1 and -2 secretion
Kim et al., J Cell Biochem 2003 (Neovascularization, Pathologic) : Genistein blocked VEGF/bFGF stimulated increase in TIMP-1 expression and decrease in TIMP-2 expression
Vincent et al., Arthritis Rheum 2004 : Loading or bFGF stimulation of explants induced synthesis and secretion of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ), which was inhibited by SB 402451 ... Cyclical loading of articular cartilage causes bFGF dependent activation of ERK and synthesis of TIMP-1
Nakoman et al., Biochimie 2005 (Carcinoma...) : The effect of bFGF on MMP-2, TIMP-2 , total collagen, and type I collagen levels of normal and carcinoma lung fibroblast cultures was investigated at 0, 10, and 100 ng/ml. Statistical analysis was carried out using the Mann-Whitney-U test and possible correlations were searched using the Spearman correlation analysis method ... It may be concluded that bFGF does not affect MMP-2, TIMP-2 , total collagen, and type-1 collagen levels in fibroblast cultures grown from human carcinoma and normal lung tissues
Sawaji et al., Arthritis Rheum 2008 : IL-1alpha induced aggrecan breakdown was inhibited by TIMP-1 or by the N-terminal portion of TIMP-3, although FGF-2 did not affect production of the inhibitors TIMP-1 and TIMP-3 when IL-1alpha was present
Hoshi et al., In Vitro Cell Dev Biol Anim 1995 : Basic FGF stimulated TIMP-1 production and BGC cell proliferation in a dose dependent manner ... These results indicate that FGF induced TIMP-1 production by BGC may support bovine embryo development in vitro
Andersen et al., Anticancer Res 1998 (Bone Neoplasms...) : However, the induction of TIMP-1 by bFGF must proceed through a pathway different from the MMP induced pathway, i.e. a pathway unaffected by CAPL