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CSF3 — TLR2

Text-mined interactions from Literome

Fukuzono et al., Arch Biochem Biophys 2010 : We studied the effect of G-CSF on TLR agonist induced cytokine production in human neutrophils ... G-CSF and GM-CSF did not affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... G-CSF mediated STAT3 phosphorylation and inhibition of TLR agonist induced cytokine production were prevented by pretreatment of cells with AG-490 ( JAK2 inhibitor ) ... These findings suggest that G-CSF and GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3
Joo et al., Cytokine 2011 : We found that PBSCs highly expressed TLR2 in comparison to BMSCs, and TLR2 was directly induced by G-CSF signaling
Wilhelmsen et al., Innate Immun 2012 (Sepsis) : We found that TLR2 activation specifically induces the expression of the genes IL-6, IL-8, CSF2, CSF3 , ICAM1 and SELE by human umbilical vein ECs and human lung microvascular ECs
Kim et al., Cytokine 2013 : Using neutralizing antibodies against toll like receptor (TLR) 2 and 4, we could evaluate that TLR 2 is responsible for G-CSF production by lipid-poor SAA