Gene interactions and pathways from curated databases and text-mining

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NGF — TNF

Text-mined interactions from Literome

Gadient et al., Neurosci Lett 1990 : Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes ... To examine regulation of NGF gene expression with respect to neural trauma we examined the effects of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) on NGF production in cultures of rat astroglial cells
Lebrun-Julien et al., Proc Natl Acad Sci U S A 2010 : Consistent with this, we show that proNGF induced robust expression of tumor necrosis factor alpha (TNFalpha) in Müller cells and that genetic or biochemical ablation of TNFalpha blocked proNGF induced death of retinal neurons ... Mice rendered null for p75 ( NTR ), its coreceptor sortilin, or the adaptor protein NRAGE were defective in proNGF induced glial TNFalpha production and did not undergo proNGF induced retinal ganglion cell death
Raychaudhuri et al., Scand J Rheumatol 2009 (Arthritis...) : FACS studies showed that unstimulated FLS expressed low levels of NGF and the high-affinity NGF-tyrosine kinase receptor TrkA, and TNFalpha and IL-1beta increased NGF and TrkA expression in FLS
Hattori et al., J Biol Chem 1993 : Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells ... TNF stimulates the synthesis and secretion of NGF also in other cells such as human glioblastoma cells
Barouch et al., J Leukoc Biol 2001 (MAP Kinase Signaling System) : In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the effect of NGF on tumor necrosis factor (TNF)-alpha production ... The induction of TNF-alpha production by NGF was blocked by K252a, an inhibitor of the TrkA receptor
Aloe et al., Brain Res 1999 (Nervous System Diseases) : In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system ( CNS ), one characterized by reactive gliosis, inflammatory demyelination and neurological deficits ( Tg6074 ) the other showing no neurological or phenotypical alterations ( TgK3 ) to investigate the effect of TNF-alpha on brain nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) levels and learning abilities
Gölz et al., Eur J Neurosci 2006 : TNFalpha inhibited NT-3-, NT-3 + NGF- , NT-4 + NGF- and NT-3 + NT-4 + NGF induced outgrowth
Caroleo et al., Alcohol 2004 : Because NGF has been reported to affect the synthesis of proinflammatory cytokines, we also evaluated whether the production of tumor necrosis factor-alpha would be affected by ethanol mediated changes in NGF synthesis
Manni et al., Clin Exp Rheumatol 2003 (Inflammation...) : Both interleukin-1-beta (IL-1 beta) and TNF-alpha , but not CCK-8 promote NGF synthesis and release from OA cells
Wang et al., Pflugers Arch 2006 (Inflammation) : In contrast, TNF-alpha induced rapid and substantial increases in expression of the genes encoding IL-6, MCP-1, NGF and TNF-alpha itself ; IL-6 and TNF-alpha mRNA levels peaked at 2 h with 75-fold and 600-fold increases, respectively ... The adipokine secretion pattern largely paralleled cellular mRNA levels ; IL-6 ( transiently ), MCP-1, NGF and VEGF release were stimulated by TNF-alpha , with an accelerating rate of MCP-1 secretion over 24 h. TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes, with highly gene-specific responses
Ma et al., Infect Immun 2004 : Our experiments were designed to explore the mechanism of effect of L. reuteri in the human epithelial cell lines T84 and HT29 on cytokine and NGF synthesis and IL-8 response to tumor necrosis factor alpha (TNF-alpha)
Smith et al., Biochem Biophys Res Commun 1991 : T2 binding of TNF is not inhibited by nerve growth factor , although the nerve growth factor receptor is also a member of the same family, nor by nine other recombinant cytokines
Brodie , FEBS Lett 1996 : Moreover, INF-gamma completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNF-alpha
Takei et al., Mol Biol Cell 2008 (Neuroblastoma...) : We find that NGF can induce TNF-alpha synthesis through the nuclear factor-kappaB transcription factor ... Thus, NGF and NGF induced TNF-alpha cooperate to activate Akt, promoting survival of normal neural cells ... However, the NGF induced TNF-alpha suppresses Erk activation by NGF, blocking NGF induced differentiation of neuroblastoma cells
Golan et al., Cereb Cortex 2004 : Moreover, lack of TNFalpha increased the expression of nerve growth factor (NGF) , but not brain derived neurotrophic factor (BDNF), following performance of the learning task
Taishi et al., Brain Res 2008 : IL1beta icv, but not TNFalpha , increased NGF mRNA levels in both these areas
Plüss et al., Biochem J 1995 : We found that co-stimulation of rat glomerular mesangial cells with platelet derived growth factor ( PGDF-BB ) and IL-1 beta/TNF-alpha significantly augments the IL-1 beta/TNF-alpha induced NGF mRNA levels and NGF synthesis ... In contrast, preincubation with PDGF-BB drastically reduces NGF gene expression and NGF protein synthesis in response to IL-1 beta/TNF-alpha stimulation
Bläsing et al., Arch Dermatol Res 2005 : By immunohistology, IFNgamma, IL-1beta, and TNF-alpha as well as a cocktail of all three cytokines increased NGF immunoreactivity ( IR ) in the proximal outer root sheath and hair matrix of anagen VI pelage hair follicles
Lee et al., J Orthop Res 2011 (Intervertebral Disc Degeneration...) : In this study, we investigated the effects of inflammatory cytokines, IL-1ß, and TNF-a , on the expression of an angiogenic factor, vascular endothelial growth factor ( VEGF ), and neurotrophic factors, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), in human IVD degeneration ... IL-1ß and TNF-a stimulated the gene expression of VEGF, NGF , and BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues
Steiner et al., Am J Physiol 1991 : Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor synthesis in rat mesangial cells
Hsieh et al., J Comp Neurol 2012 (Neuralgia) : We investigated the effects of low-level laser on the accumulation of HIF-1a, tumor necrosis factor-a (TNF-a), and interleukin-1ß (IL-1ß) in controlling neuropathic pain, as well as on the activation of vascular endothelial growth factor ( VEGF ) and nerve growth factor (NGF) in promoting functional recovery in a rat CCI model
Galve-Roperh et al., J Neurochem 1998 : Evidence for the lack of involvement of sphingomyelin hydrolysis in the tumor necrosis factor induced secretion of nerve growth factor in primary astrocyte cultures ... Because ceramide is also able to induce NGF secretion and because TNF alpha is a known agonist of the sphingomyelin ( SPM ) -ceramide pathway, we investigated whether the TNF alpha induced NGF secretion by primary astrocytes is mediated by ceramide ... Altogether, our data strongly suggest that TNF alpha mediated up-regulation of NGF occurs independently of ceramide generation
Nagatsu et al., J Neural Transm Suppl 2000 (Parkinson Disease...) : In experimental animal models of PD, IL-1beta level was increased and NGF one decreased in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) -induced parkinsonian mice, and TNF-alpha level was increased in the substantia nigra and striatum of the 6-hydroxydopamine ( 6OHDA ) -injected side of hemiparkinsonian rats
Patterson et al., Endocrinology 1994 : In addition, GH releasing hormone, tumor necrosis factor-alpha , basic fibroblast growth factor, and forskolin all caused an inhibition of NGF secretion below basal levels
Hattorl et al., Biochem Mol Biol Int 1996 : Although TGF-beta 1 and Activin A stimulated NGF production in Swiss 3T3 cells, they antagonized the stimulatory effect of TNF on fibroblast NGF production when used in combination
Jiang et al., J Immunol 2007 : NGF could markedly promote LPS induced expression of HLA-DR, CD40, CD80, CD83, CD86, CCR7, secretion of IL-12p40 and proinflammatory cytokines IL-1, IL-6, TNF-alpha , and the T cell stimulating capacity of MoDCs, indicating that NGF can promote LPS induced DC maturation
Marshall et al., J Immunol 1999 : We have observed that NGF at doses as low as 10 ng/ml will induce IL-6 production and inhibit TNF-alpha release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor
Abe et al., Spine (Phila Pa 1976) 2007 (Cadaver) : The effects of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) on NGF production and mRNA expression of NGF by IVD cells were examined ... IL-1beta and TNF-alpha up-regulated the NGF mRNA expression and the secretion of NGF protein into the media
Manni et al., Rheumatol Int 1998 (Arthritis, Experimental) : Role of IL-1 beta and TNF-alpha in the regulation of NGF in experimentally induced arthritis in mice ... The aim of this study was to investigate the effects of IL-1 beta and TNF-alpha on NGF levels in the knee joint in experimentally induced arthritis in adult mice ... Out data showed that IL-1 beta, but not TNF-alpha , induces an increase in NGF levels, while concomitant injection of both cytokines enhances the effect of IL-1 beta on NGF presence
Al-Gayyar et al., PloS one 2013 (Diabetes Mellitus, Experimental...) : While proNGF induced TNF-a expression in vivo, it selectively activated RhoA in primary RGC cultures and RGC-5 cell line
Manna et al., J Cell Physiol 2006 : In this report we provide evidences that oleandrin, a cardiac glycoside potentially inhibited IL-8-, formyl peptide ( FMLP ) -, EGF-, or nerve growth factor (NGF)- , but not IL-1- or TNF induced NF-kappaB activation in macrophages