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RPL17 — TNF
Text-mined interactions from Literome
Nakae et al., J Immunol 2006
:
We found that IgE- and Ag-dependent mast cell enhancement of T cell activation required secreted TNF ; that
TNF can
increase the surface expression of OX40, ICOS,
PD-1 , and other costimulatory molecules on CD3 ( + ) T cells ; and that a neutralizing Ab to OX40L, but not neutralizing Abs to ICOSL or PD-L1, significantly reduced IgE/Ag dependent mast cell mediated enhancement of T cell activation
Boswell-Smith et al., J Pharmacol Exp Ther 2006
(Pneumonia) :
RPL554 and RPL565
inhibited , in a concentration dependent manner, lipopolysaccharide induced
tumor necrosis factor alpha release from human monocytes [ IC50 ; 0.52 microM ( 0.38-0.69 ) and 0.25 microM ( 0.18-0.35 ), respectively ] and proliferation of human mononuclear cells to phytohemagglutinin [ IC50 ; 0.46 microM ( 0.24-0.9 ) and 2.90 microM ( 1.6-5.4 ), respectively ]
Wei et al., Proc Natl Acad Sci U S A 2013
(Calcium Signaling) :
We observed that high levels of PD-1 expression were required to inhibit macrophage inflammatory protein 1 beta production, lower levels were required to block cytotoxicity and IFN-? production, and very low levels of
PD-1 expression could
inhibit TNF-a and IL-2 production as well as T-cell expansion