Gene interactions and pathways from curated databases and text-mining

◀ Back to RPL17

RPL17 — TNF

Text-mined interactions from Literome

Nakae et al., J Immunol 2006 : We found that IgE- and Ag-dependent mast cell enhancement of T cell activation required secreted TNF ; that TNF can increase the surface expression of OX40, ICOS, PD-1 , and other costimulatory molecules on CD3 ( + ) T cells ; and that a neutralizing Ab to OX40L, but not neutralizing Abs to ICOSL or PD-L1, significantly reduced IgE/Ag dependent mast cell mediated enhancement of T cell activation
Boswell-Smith et al., J Pharmacol Exp Ther 2006 (Pneumonia) : RPL554 and RPL565 inhibited , in a concentration dependent manner, lipopolysaccharide induced tumor necrosis factor alpha release from human monocytes [ IC50 ; 0.52 microM ( 0.38-0.69 ) and 0.25 microM ( 0.18-0.35 ), respectively ] and proliferation of human mononuclear cells to phytohemagglutinin [ IC50 ; 0.46 microM ( 0.24-0.9 ) and 2.90 microM ( 1.6-5.4 ), respectively ]
Wei et al., Proc Natl Acad Sci U S A 2013 (Calcium Signaling) : We observed that high levels of PD-1 expression were required to inhibit macrophage inflammatory protein 1 beta production, lower levels were required to block cytotoxicity and IFN-? production, and very low levels of PD-1 expression could inhibit TNF-a and IL-2 production as well as T-cell expansion