◀ Back to CSF1
CSF1 — TNFRSF11B
Text-mined interactions from Literome
Wise et al., J Dent Res 2000
:
In vitro studies demonstrated that both
colony stimulating factor-1 and parathyroid hormone related protein
reduced OPG gene expression in follicle cells, suggesting that these are candidate molecules for the in vivo inhibition of OPG expression
Hayashi et al., Endocrinology 2004
:
This
M-CSF plus LPS induced osteoclastogenesis was not
inhibited by an anti-TNFalpha antagonistic antibody or by
osteoprotegerin , a decoy receptor for RANKL
Yamada et al., Cytokine 2005
:
To delineate mechanisms involved, the
effect of
M-CSF on the production of
osteoprotegerin (OPG) , decoy receptor of RANKL, in BMMs was investigated ...
M-CSF inhibited both the
OPG mRNA expression and the OPG secretion dose-dependently and reversibly ... The results showed that
M-CSF suppresses the
OPG production in BMMs, which may increase the sensitivity of BMMs to RANKL
Wise et al., J Dent Res 2005
:
Thus, these studies support our hypothesis that the down-regulation of
OPG needed for tooth eruption is
mediated by
CSF-1