◀ Back to JUN
JUN — TNFSF10
Text-mined interactions from Literome
Milani et al., J Neurochem 2003
(Neuroblastoma) :
TRAIL rapidly ( from 20 min )
induced the phosphorylation of Akt and ERK, but not of
c-Jun NH2-terminal kinase (JNK)
Mahalingam et al., Br J Cancer 2009
(Colonic Neoplasms) :
TRAIL can also
activate c-Jun N-terminal kinase (JNK) through the adaptor molecules, TNF receptor associated factor 2 (TRAF2) and receptor interacting protein ( RIP )
Tang et al., Biol Pharm Bull 2009
(Liver Cirrhosis) :
A771726 did not increase the expression of TRAIL receptors in LX-2 cells but could inhibit activation of the c-Jun NH2-terminal kinase (JNK) pathway through decreasing
TRAIL induced JNK and
c-Jun phosphorylation
Fujikawa et al., Clin Exp Rheumatol 2009
:
TRAIL rapidly
induced apoptosis of FLS as well as the phosphorylation of extracellular signal regulated kinase ( ERK ), p38,
c-Jun N-terminal kinase (JNK) and Akt
Sun et al., Oncol Rep 2011
:
We found that MEKK1/MEKK4 as opposed to ASK1, are responsible for
TRAIL induced
c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation
Badmann et al., Cell death & disease 2011
(Drug-Induced Liver Injury) :
We recently identified
TNF related apoptosis inducing ligand ( TRAIL ) and
c-Jun kinase (JNK) dependent
activation of the pro-apoptotic Bcl-2 homolog Bim as an important apoptosis amplification pathway in hepatocytes
Cheng et al., Cell cycle (Georgetown, Tex.) 2012
(Neoplasms) :
Induction of DR4 and DR5 was independent of p53, Bax and Bim but was
dependent on
c-Jun N terminal kinase (JNK) as JNK pharmacological inhibition and siRNA abolished the induction of the
TRAIL receptors by MMC
Portanova et al., Int J Oncol 2013
:
Notch inhibition restores TRAIL mediated apoptosis via
AP1 dependent upregulation of DR4 and DR5
TRAIL receptors in MDA-MB-231 breast cancer cells
Mühlenbeck et al., J Biol Chem 1998
:
TRAIL/Apo2L activates
c-Jun NH2-terminal kinase (JNK) via caspase dependent and caspase independent pathways ... In this study we show that
TRAIL ( tumor necrosis factor related apoptosis inducing ligand ), also called Apo2L,
activates the
c-Jun N-terminal kinase (JNK)