Gene interactions and pathways from curated databases and text-mining

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JUN — TNFSF10

Text-mined interactions from Literome

Milani et al., J Neurochem 2003 (Neuroblastoma) : TRAIL rapidly ( from 20 min ) induced the phosphorylation of Akt and ERK, but not of c-Jun NH2-terminal kinase (JNK)
Mahalingam et al., Br J Cancer 2009 (Colonic Neoplasms) : TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor molecules, TNF receptor associated factor 2 (TRAF2) and receptor interacting protein ( RIP )
Tang et al., Biol Pharm Bull 2009 (Liver Cirrhosis) : A771726 did not increase the expression of TRAIL receptors in LX-2 cells but could inhibit activation of the c-Jun NH2-terminal kinase (JNK) pathway through decreasing TRAIL induced JNK and c-Jun phosphorylation
Fujikawa et al., Clin Exp Rheumatol 2009 : TRAIL rapidly induced apoptosis of FLS as well as the phosphorylation of extracellular signal regulated kinase ( ERK ), p38, c-Jun N-terminal kinase (JNK) and Akt
Sun et al., Oncol Rep 2011 : We found that MEKK1/MEKK4 as opposed to ASK1, are responsible for TRAIL induced c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation
Badmann et al., Cell death & disease 2011 (Drug-Induced Liver Injury) : We recently identified TNF related apoptosis inducing ligand ( TRAIL ) and c-Jun kinase (JNK) dependent activation of the pro-apoptotic Bcl-2 homolog Bim as an important apoptosis amplification pathway in hepatocytes
Cheng et al., Cell cycle (Georgetown, Tex.) 2012 (Neoplasms) : Induction of DR4 and DR5 was independent of p53, Bax and Bim but was dependent on c-Jun N terminal kinase (JNK) as JNK pharmacological inhibition and siRNA abolished the induction of the TRAIL receptors by MMC
Portanova et al., Int J Oncol 2013 : Notch inhibition restores TRAIL mediated apoptosis via AP1 dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231 breast cancer cells
Mühlenbeck et al., J Biol Chem 1998 : TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase dependent and caspase independent pathways ... In this study we show that TRAIL ( tumor necrosis factor related apoptosis inducing ligand ), also called Apo2L, activates the c-Jun N-terminal kinase (JNK)