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CSF1 — TNFSF11
Text-mined interactions from Literome
Jimi et al., J Immunol 1999
:
The soluble form of
ODF ( sODF ) induces the differentiation of osteoclast precursors into osteoclasts in the
presence of
M-CSF
Atkins et al., J Bone Miner Res 2000
(Bone Neoplasms...) :
ODF was shown to directly stimulate osteoclastogenesis, in the
presence of
M-CSF
Itoh et al., J Bone Miner Res 2000
:
These findings suggest that the up-regulation of
RANKL/ODF expression is an essential step for PTH induced osteoclastogenesis, and membrane- or matrix associated forms of both
M-CSF and RANKL/ ODF are essentially
involved in osteoclast formation supported by osteoblasts/stromal cells
Cappellen et al., J Biol Chem 2002
:
In conclusion,
M-CSF induced genes necessary for a direct response to RANKL and interleukins, while
RANKL directed a three-stage differentiation program and induced genes for interaction with osteoblasts and immune and nerve cells
Gardner et al., Cell Tissue Res 2007
:
RANKL , in the
presence of
M-CSF , induces the development and fusion of TRAP+ osteoclasts in mouse bone marrow cultures at 3-5 days
Islam et al., Microbiol Immunol 2008
:
RANKL augmented
M-CSF mRNA expression and M-CSF production in RAW 264.7 cells
Sanuki et al., Connect Tissue Res 2010
:
As CF increased, PGE ( 2 ) production and the expression of COX-2,
M-CSF , and
RANKL increased , whereas OPG expression decreased
Motokawa et al., Arch Oral Biol 2013
(Bone Resorption) :
However, significant differences were found in the number of osteoclasts
induced by VEGF-A, -C, -D or
M-CSF with
RANKL compared with control groups lacking or containing RANKL
Kotake et al., In Vitro Cell Dev Biol Anim 2012
(Bone Resorption) :
Thus, these findings clearly demonstrated that human
RANKL induces primate osteoclastogenesis in the
presence of human
M-CSF