Gene interactions and pathways from curated databases and text-mining

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MMP16 — TNFSF11

Text-mined interactions from Literome

Yu et al., J Bone Miner Res 2003 (Bone Resorption) : SDF-1 versus RANKL effects on chemotaxis, transcollagen migration, MMP-9 expression and activity, OC development, and bone resorption were evaluated in RAW cells or RAW-OCs
Kaden et al., Exp Mol Pathol 2005 (Aortic Valve Stenosis...) : RANKL might regulate this process by promoting cell proliferation and MMP expression and activation
Sandberg et al., Arterioscler Thromb Vasc Biol 2006 (Angina, Unstable...) : Our findings were : ( 1 ) Serum levels of OPG were raised in patients with unstable angina ( n=40 ), but not in those with stable angina ( n=40 ), comparing controls ( n=20 ) ; ( 2 ) mRNA levels of RANKL were increased in T-cells in unstable angina patients accompanied by increased expression of RANK in monocytes ; ( 3 ) strong immunostaining of OPG/RANKL/RANK was seen within thrombus material obtained at the site of plaque rupture during acute myocardial infarction ; ( 4 ) OPG/RANKL/RANK was expressed in the atherosclerotic plaques of apoE ( -/- ) mice, with RANKL located specifically to the plaques ; and ( 5 ) RANKL enhanced the release of monocyte chemoattractant peptide-1 in mononuclear cells from unstable angina patients, and promoted matrix metalloproteinase ( MMP ) activity in vascular smooth muscle cells