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KRT8 — TP53
Text-mined interactions from Literome
Mukhopadhyay et al., Anticancer Res 1996
(Carcinoma, Non-Small-Cell Lung...) :
We show that the expression of the human
cytokeratin 8 (CK8) gene is
regulated by wild-type
p53 ... Cotransfection of the H358 p53 negative human lung cancer cell line with a CK8 promoter CAT expression vector and a plasmid expressing the wildtype p53 indicated that
p53 induces
CK8 expression ... A transient assay in which a p53 negative cell line was cotransfected with a CK8 promoter CAT expression vector and a plasmid expressing wildtype or mutant p53 indicated that only wildtype
p53 induces the
CK8 promoter
Mukhopadhyay et al., Anticancer Res 1996
(Carcinoma, Non-Small-Cell Lung...) :
Previously we had identified a p53 DNA binding motif in the 5 ' region of the CK8 gene This finding led us to study the
role of
p53 protein in the regulation of
CK8 gene expression and its role in tumorigenesis