Gene interactions and pathways from curated databases and text-mining

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NOS1 — TP53

Text-mined interactions from Literome

Hsieh et al., Cancer Res 1999 : Resveratrol increases nitric oxide synthase , induces accumulation of p53 and p21 ( WAF1/CIP1 ), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2
Mortensen et al., J Biol Chem 1999 (Breast Neoplasms) : Endogenous endothelial cell nitric-oxide synthase modulates apoptosis in cultured breast cancer cells and is transcriptionally regulated by p53
Blanco et al., Neoplasia (New York, N.Y.) 2007 (Chronic Disease...) : Our results showed DDR pathway activation in preneoplastic lesions, in association with inducible nitric oxide synthase and p53 induction
Chernigovskaya et al., Biotech Histochem 2011 : Thus, we demonstrated that gene disruption of nNOS prevents activation of Bcl-2, p53 and caspase-9 expression during water deprivation, and that nNOS deficiency did not affect survival of magnocellular neurons of the hypothalamus