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CASP8 — TRAF2
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
Complex of CASP8-FADD-IKBKG-RALBP1-TRAF2
→
TNFSF10
(increases)
Varfolomeev et al., J Biol Chem 2005*
Evidence: Here we show that Apo2L/TRAIL activates kinase pathways by promoting the association of a secondary signaling complex, subsequent to assembly of a primary, death-inducing signaling complex (DISC). The secondary complex retained the DISC components FADD and caspase-8, but recruited several factors involved in kinase activation by TNF, namely, RIP1, TRAF2, and NEMO/IKKgamma.
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BioCarta induction of apoptosis through dr3 and dr4/5 death receptors:
DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12)
→
APO-3L (TNFSF12)
(modification, collaborate)
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BioCarta induction of apoptosis through dr3 and dr4/5 death receptors:
DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12)
→
DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10 complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10)
(modification, collaborate)
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BioCarta induction of apoptosis through dr3 and dr4/5 death receptors:
APO-3L (TNFSF12)
→
DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10 complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10)
(modification, collaborate)
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BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD/Caspase 8 complex (CASP8-FADD)
(modification, activates)
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BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 8 (CASP8)
(modification, activates)
-
BioCarta induction of apoptosis through dr3 and dr4/5 death receptors:
DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12)
→
Caspase 3 (CASP3)
(modification, activates)
-
BioCarta induction of apoptosis through dr3 and dr4/5 death receptors:
DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12)
→
Caspase 3 (active) (CASP3)
(modification, activates)
-
BioCarta ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta induction of apoptosis through dr3 and dr4/5 death receptors:
DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12)
→
MAP3K14
(modification, activates)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
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NCI Pathway Database Ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
Boldin et al., Cell 1996, Muzio et al., Cell 1996
Evidence: assay
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NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caspase 8 (CASP8)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
CASP8
→
TRAF2
(indirect_complex)
Donepudi et al., Mol Cell 2003, Micheau et al., Cell 2003, Rushworth et al., Cell cycle (Georgetown, Tex.) 2008*, Wang et al., Cell 2008*, Seal et al., Exp Hematol 2008*, Vittori et al., Cell Biol Int 2010*
-
Reactome Reaction:
CASP8
→
TRAF2
(reaction)
Donepudi et al., Mol Cell 2003, Micheau et al., Cell 2003, Wang et al., Cell 2008*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
TRAF2
—
CASP8
(physical association, affinity chromatography technology)
Gonzalvez et al., Mol Cell 2012
-
IRef Biogrid Interaction:
TRAF2
—
CASP8
(physical association, affinity chromatography technology)
Micheau et al., Cell 2003
-
IRef Biogrid Interaction:
TRAF2
—
CASP8
(physical association, affinity chromatography technology)
Knox et al., J Cell Biol 2011*
-
IRef Biogrid Interaction:
TRAF2
—
CASP8
(physical association, affinity chromatography technology)
Mahul-Mellier et al., Cell Death Differ 2012
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Micheau et al., Cell 2003
-
IRef Hprd Interaction:
TRAF2
—
CASP8
(in vitro)
Choi et al., J Biol Chem 2001*, Varfolomeev et al., J Biol Chem 2005*
-
IRef Hprd Interaction:
TRAF2
—
CASP8
(in vivo)
Choi et al., J Biol Chem 2001*, Varfolomeev et al., J Biol Chem 2005*
-
IRef Innatedb Interaction:
TRAF2
—
CASP8
(unknown, -)
Rébé et al., Blood 2007
-
IRef Intact Interaction:
Complex of TRAF2-RIPK1-TRADD-FADD-CASP8-CFLAR
(association, anti bait coimmunoprecipitation)
Rébé et al., Blood 2007
-
IRef Intact Interaction:
Complex of TRAF2-TRAF1-TRADD-FADD-CASP8-CFLAR-BIRC2-RIPK1
(association, anti bait coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of CASP8-CASP10-CFLAR-TRADD-TRAF2-RIPK1-FADD
(association, anti bait coimmunoprecipitation)
Micheau et al., Cell 2003
Text-mined interactions from Literome
Hentze et al., Hepatology 2004
:
CPT treatment completely abrogated the TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors
TNF-receptor associated factor 2 , FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also
inhibited by CPT. The
caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Conti et al., J Neurosurg 2005
(Brain Neoplasms...) :
The authors investigated the expression of NF-kappaB,
caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a
regulator of
TRAF activity, in human gliomas
Georgopoulos et al., Cell Death Differ 2006
(Urologic Neoplasms) :
Thus,
TRAF3 stabilization, JNK activation and
caspase-9 induction define a novel pathway of CD40 mediated apoptosis in carcinoma cells