Gene interactions and pathways from curated databases and text-mining

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RELA — TRAF4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Puls et al., J Cell Sci 1999 (Inflammation) : Using LMP1 mutants, we show that activation of Cdc42 and JNK/NF(kappa)B occur through distinct pathways and that Cdc42 activation is independent of LMP1 's interaction with TRADD and TRAF proteins
Ye et al., J Biol Chem 1999 : TRAF4 also inhibited the NF-kappaB response, whereas TRAF2 and TRAF6 enhanced p75 ( NTR ) -induced NF-kappaB activation
Pomerantz et al., EMBO J 1999 : However, TANK also displays the ability to stimulate TRAF mediated NF-kappaB activation ... The TBK1-TANK-TRAF2 signaling complex functions upstream of NIK and the IKK complex and represents an alternative to the receptor signaling complex for TRAF mediated activation of NF-kappaB
Nomura et al., Genes Cells 2000 : NF-kappaB activation by IKK-i is significantly blocked by coexpression of the N-terminal domain of I-TRAF , dominant negative TRAF2, and dominant negative NIK and IKK-beta
Zapata et al., J Biol Chem 2000 : In contrast, TRAF2 mediated NFkappaB induction was partially inhibited by DTRAF1
Takaori-Kondo et al., Biochem Biophys Res Commun 2000 : TRAF3 blocked OX40-, TRAF2 induced NF-kappaB activation, but not NIK- and IKKalpha induced NF-kappaB activation , indicating that TRAF3 blocks the pathway between TRAF2 and NIK
Chandel et al., J Biol Chem 2001 : Consistent with its anti-apoptotic function, Bcl-x ( L ) interfered with TRAF mediated ROS generation but not NF-kappaB activation
Naito et al., Proc Natl Acad Sci U S A 2002 (Ectodermal Dysplasia) : Furthermore, TRAF6 is essential for the XEDAR mediated NFkappaB activation
Wu et al., Gene Expr 2002 : In addition, ZAS3 associates with a TNF receptor associated factor to inhibit NF-kappaB- and JNK/ SAPK mediated signaling of TNF-alpha
Lee et al., J Biochem Mol Biol 2002 : The inhibitory effect of the TAK1 mutant on RANK- and TRAF induced NF-kappaB activation was also observed, but less efficiently
Henkler et al., J Biol Chem 2003 : The role of tumor necrosis factor (TNF) receptor associated factor ( TRAF)-1 in NF-kappaB activation by various members of the TNF receptor family is not well understood, and conflicting data have been published
Bin et al., J Biol Chem 2003 : Moreover, TIRP mediated NF-kappaB activation is inhibited by dominant negative mutants of IRAK, IRAK-2, TRAF6 , and IKKbeta
Sakon et al., EMBO J 2003 : Importantly, TNF does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs, indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death
Fotin-Mleczek et al., J Biol Chem 2004 : Accordingly, TRAF1 inhibited CD40 dependent but not TNF-R1 dependent NF-kappaB activation
Takada et al., J Biol Chem 2004 : NF-kappaB reporter activity induced by TNF receptor 1, TNF receptor associated death domain, TNF receptor associated factor-2 , NF-kappaB inducing kinase, and IkappaBalpha kinase, were all blocked by flavopiridol but not that activated by p65
Esparza et al., Cell Mol Life Sci 2004 : Further analyses revealed that TRAF4 mediated NF-kappaB activation downstream of GITR depends on a previously mapped TRAF binding site in the cytoplasmic domain of the receptor and is inhibited by the cytoplasmic protein A20
Min et al., J Immunol 2005 : TNF related activation induced cytokine enhances leukocyte adhesiveness : induction of ICAM-1 and VCAM-1 via TNF receptor associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells
Shishodia et al., Cancer Res 2005 (Carcinoma, Small Cell...) : NF-kappaB dependent reporter gene expression was also suppressed by 4-HPR, as was NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKK but not that induced by p65 transfection
Morlon et al., Hum Mol Genet 2005 (Ectodermal Dysplasia) : TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd ... Moreover, we show that dominant negative forms of TAB2, TRAF6 and TAK1 blocked the NF-kappaB activation induced by Edaradd
Conti et al., J Neurosurg 2005 (Brain Neoplasms...) : The authors investigated the expression of NF-kappaB , caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a regulator of TRAF activity, in human gliomas
Sethi et al., J Biol Chem 2006 : NF-kappaB reporter activity induced by TNFR1, TNF receptor associated death domain, TRAF2 , TAK1, NF-kappaB inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection
Ryu et al., World J Gastroenterol 2006 (Hepatitis B) : During the initial state of HBV infection, hepatocytes facilitate the activation of NF-kappaB through up regulation of LT-alpha, TRAF2 , and NIK
Noels et al., J Biol Chem 2007 (Lymphoma, B-Cell, Marginal Zone...) : In contrast, TRAF6 was essential for NF-kappaB activation by all fusion variants, and we identified a novel TRAF6 binding site in the second immunoglobulin domain of MALT1, which enhanced NF-kappaB activation when present in the fusion protein
Sung et al., Mol Pharmacol 2007 : NF-kappaB dependent reporter gene expression was also suppressed by fisetin, as was NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKK but not that induced by p65 transfection
Sethi et al., Oncogene 2007 (Adenocarcinoma...) : Using dominant negative plasmids, we also demonstrated the role of TRADD, TRAF2 , NIK and Ras in EGF induced NF-kappaB activation
Sethi et al., J Immunol 2007 : NF-kappaB reporter assay revealed that NF-kappaB activation induced by TNF, TNFR1, TRADD, TRAF2 , NIK, and I kappaB alpha kinase was modulated in gene deleted cells
Zarnegar et al., Proc Natl Acad Sci U S A 2008 : Studies examining tumor-necrosis factor receptor associated factors ( TRAFs ) have identified positive roles for TRAF2, TRAF5 , and TRAF6, but not TRAF3, in canonical ( p50 dependent ) NF-kappaB activation
Sethi et al., Biochem Pharmacol 2008 (Neoplasm Invasiveness) : This led to suppression of the phosphorylation and translocation of p65 and also of NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKKbeta but not that induced by p65 transfection
Blackwell et al., Mol Cell Biol 2009 (Lymphoma) : Notably, TRAF2 phosphorylation increased both basal and inducible c-Jun and NF-kappaB activities and rendered cells resistant to stress induced apoptosis
Graham et al., J Immunol 2009 : Examination of TRAF binding, degradation, cytokine production, IgM secretion, and the activation of c-Jun kinase and NF-kappaB revealed that some events are dictated by TRAF binding site sequences, others are partially regulated, and still others are independent of the TRAF binding site sequence
Yamazaki et al., Science signaling 2009 : After TAK1 mediated activation of NF-kappaB, TRAF6 subsequently activated NF-kappaB through MEKK3 independently of TAK1, thereby establishing continuous activation of NF-kappaB, which was required for the production of sufficient cytokines
Manna et al., J Biol Chem 2010 : It inhibits TRAF2 mediated NF-kappaB activation but not TRAF6 mediated NF-kappaB DNA binding by preventing its association with TANK ( TRAF for NF-kappaB )
Tewari et al., Curr Opin Genet Dev 1996 : Significantly, TRAF2 mediates the activation of NF-kappa B by both receptors
Cao et al., Nature 1996 : When overexpressed in human 293 cells, TRAF6 activates NF-kappaB
Duckett et al., Mol Cell Biol 1997 : TRAF dependent induction of NF-kappaB appears to be regulated by the relative levels of individual TRAF proteins in the cell
Wong et al., J Biol Chem 1998 : Dominant negative forms of TRAF2, TRAF5 , and TRAF6 and an endogenous inhibitor of TRAF2, TRAF interacting protein (TRIP), substantially inhibited TRANCE-R mediated NF-kappaB activation, suggesting a role of TRAFs in regulating DC and osteoclast function