Gene interactions and pathways from curated databases and text-mining

◀ Back to BECN1

BECN1 — UVRAG

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Liang et al., Nat Cell Biol 2006 (Carcinoma...) : UVRAG, a tumour suppressor candidate that is monoallelically mutated at high frequency in human colon cancers, associates with the Beclin1-Bcl-2-PI(3)KC3 multiprotein complex, where UVRAG and Beclin1 interdependently induce autophagy ... UVRAG mediated activation of the Beclin1-PI(3)KC3 complex promotes autophagy and also suppresses the proliferation and tumorigenicity of human colon cancer cells
Noble et al., J Biol Chem 2008 : UVRAG disrupts the Beclin1-dimer interface, forming a heterodimer with Beclin1, suggesting that this is how UVRAG causes its effects on Beclin1 to activate autophagy ... Moreover, coimmunoprecipitation assays show that UVRAG substantially reduces Beclin1 dimerization in vivo
Yin et al., Autophagy 2011 : UVRAG ( UV radiation resistance associated gene ), a mammalian homolog of yeast Vps38, activates the Beclin 1/PtdIns3KC3 ( class III phosphatidylinositol-3-kinase ) complex, which promotes autophagosome formation