◀ Back to BECN1
BECN1 — UVRAG
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
BECN1
—
UVRAG
(physical association, affinity chromatography technology)
Behrends et al., Nature 2010
-
IRef Dip Interaction:
Complex of ATG14-TP63-PIK3R4-PIK3C3-UVRAG-BECN1-PIK3CG
(anti tag coimmunoprecipitation)
Sun et al., Proc Natl Acad Sci U S A 2008
-
IRef Dip Interaction:
Complex of BECN1-BECN1-UVRAG-UVRAG-ATG14-ATG14
(anti tag coimmunoprecipitation)
Sun et al., Proc Natl Acad Sci U S A 2008
-
IRef Dip Interaction:
BECN1
—
UVRAG
(direct interaction, anti tag coimmunoprecipitation)
Sun et al., Proc Natl Acad Sci U S A 2008
-
IRef Dip Interaction:
BECN1
—
UVRAG
(direct interaction, pull down)
Sun et al., Proc Natl Acad Sci U S A 2008
-
IRef Dip Interaction:
Complex of PIK3C3-BCL2-UVRAG-BECN1
(anti tag coimmunoprecipitation)
Sun et al., Proc Natl Acad Sci U S A 2008
-
Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
-
IRef Intact Interaction:
Complex of 11 proteins
(physical association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
BECN1
—
UVRAG
(association, anti tag coimmunoprecipitation)
Yin et al., EMBO Rep 2011*
-
IRef Intact Interaction:
BECN1
—
UVRAG
(physical association, two hybrid)
Criollo et al., EMBO J 2011
-
IRef Intact Interaction:
Complex of UVRAG-BECN1-BAX-BAX-BECN1-UVRAG
(association, anti bait coimmunoprecipitation)
Yin et al., EMBO Rep 2011*
-
IRef Intact Interaction:
Complex of ATG14-PIK3C3-BECN1-AMBRA1-KIAA0226-UVRAG
(association, anti tag coimmunoprecipitation)
He et al., Cell 2013
-
IRef Intact Interaction:
Complex of 25 proteins
(physical association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
Complex of 11 proteins
(physical association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
Complex of 22 proteins
(association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
Complex of 32 proteins
(association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
Text-mined interactions from Literome
Liang et al., Nat Cell Biol 2006
(Carcinoma...) :
UVRAG, a tumour suppressor candidate that is monoallelically mutated at high frequency in human colon cancers, associates with the
Beclin1-Bcl-2-PI(3)KC3 multiprotein complex, where
UVRAG and Beclin1 interdependently
induce autophagy ...
UVRAG mediated activation of the
Beclin1-PI(3)KC3 complex promotes autophagy and also suppresses the proliferation and tumorigenicity of human colon cancer cells
Noble et al., J Biol Chem 2008
:
UVRAG disrupts the Beclin1-dimer interface, forming a heterodimer with Beclin1, suggesting that this is how
UVRAG causes its effects on
Beclin1 to activate autophagy ... Moreover, coimmunoprecipitation assays show that
UVRAG substantially
reduces Beclin1 dimerization in vivo
Yin et al., Autophagy 2011
:
UVRAG ( UV radiation resistance associated gene ), a mammalian homolog of yeast Vps38,
activates the
Beclin 1/PtdIns3KC3 ( class III phosphatidylinositol-3-kinase ) complex, which promotes autophagosome formation