Gene interactions and pathways from curated databases and text-mining

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PTEN — VCAM1

Text-mined interactions from Literome

Tsoyi et al., Atherosclerosis 2009 : Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide induced VCAM-1 but not ICAM-1 expression in human endothelial cells ... Our results indicate that upregulation of PTEN by CKD712 selectively inhibit VCAM-1 expression in LPS treated HUVECs
Tsoyi et al., Atherosclerosis 2010 : PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3ß/GATA-6 signaling pathways in TNF-a activated human endothelial cells ... PTEN strongly inhibited VCAM-1 but not ICAM-1, however this inhibitory effect was reversed by co-transfection with constitutively active-Akt ( CA-Akt-HA ) in TNF-a stimulated ECs ... It is concluded that PTEN selectively inhibits expression of VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3ß/GATA-6 signaling cascade in TNF-a treated ECs