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PTEN — VCAM1
Text-mined interactions from Literome
Tsoyi et al., Atherosclerosis 2009
:
Upregulation of
PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively
inhibits lipopolysaccharide induced
VCAM-1 but not ICAM-1 expression in human endothelial cells ... Our results indicate that upregulation of
PTEN by CKD712 selectively
inhibit VCAM-1 expression in LPS treated HUVECs
Tsoyi et al., Atherosclerosis 2010
:
PTEN differentially
regulates expressions of ICAM-1 and
VCAM-1 through PI3K/Akt/GSK-3ß/GATA-6 signaling pathways in TNF-a activated human endothelial cells ...
PTEN strongly
inhibited VCAM-1 but not ICAM-1, however this inhibitory effect was reversed by co-transfection with constitutively active-Akt ( CA-Akt-HA ) in TNF-a stimulated ECs ... It is concluded that
PTEN selectively
inhibits expression of
VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3ß/GATA-6 signaling cascade in TNF-a treated ECs