Gene interactions and pathways from curated databases and text-mining

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CSF1 — VEGFA

Text-mined interactions from Literome

Eubank et al., J Immunol 2003 : M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes ... In this study we demonstrate that recombinant human M-CSF induces freshly isolated normal human monocytes to produce and release the growth factor vascular endothelial growth factor ( VEGF ) in a dose dependent manner, which peaked at 5 days in culture ... Network formation by these HUVECs after treatment with supernatants from monocytes stimulated with M-CSF were inhibited by anti-VEGF, but not by the isogenic control, Abs. Collectively, these data support an important role for M-CSF and monocytes in VEGF production and angiogenesis
Okazaki et al., J Immunol 2005 (Carcinoma, Lewis Lung...) : In vivo, M-CSF increased VEGF mRNA expression in skeletal muscles ... Even after treatment with carageenan and anti-CD11b mAb in mice, M-CSF increased VEGF production in skeletal muscles, suggesting that systemic VEGF elevation was attributed to skeletal muscle VEGF production ... In vitro, M-CSF increased VEGF production and activated the Akt signaling pathway in C2C12 myotubes
Varney et al., J Interferon Cytokine Res 2005 (Melanoma...) : Next, we examined the effect of MCP-1 and M-CSF on modulation of VEGFA expression in monocytes/macrophages ... In summary, we demonstrate that MCP-1 and M-CSF , critical for monocyte recruitment, activation, and differentiation, differentially regulate VEGF-A expression and may play an important role in monocyte/macrophage- mediated tumor angiogenesis
Nakano et al., Stem Cells 2006 (Disease Models, Animal...) : M-CSF augments the production of vascular endothelial growth factor ( VEGF ) from the bone marrow cells, especially from myeloid lineage cells
Okazaki et al., Am J Pathol 2007 (Myocardial Ischemia...) : Here, we show M-CSF increases VEGF production from cardiomyocytes, protects cardiomyocytes and myotubes from cell death, and improves cardiac function after ischemic injury ... In mice, M-CSF increased VEGF production in hearts and in freshly isolated cardiomyocytes, which showed M-CSF receptor expression ... In rat cell line H9c2 cardiomyocytes and myotubes, M-CSF induced VEGF production via the Akt signaling pathway, and M-CSF pretreatment protected these cells from H ( 2 ) O ( 2 ) -induced cell death