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CSF1 — VEGFA
Text-mined interactions from Literome
Eubank et al., J Immunol 2003
:
M-CSF induces
vascular endothelial growth factor production and angiogenic activity from human monocytes ... In this study we demonstrate that recombinant human
M-CSF induces freshly isolated normal human monocytes to produce and release the growth factor
vascular endothelial growth factor ( VEGF ) in a dose dependent manner, which peaked at 5 days in culture ... Network formation by these HUVECs after treatment with supernatants from monocytes stimulated with M-CSF were inhibited by anti-VEGF, but not by the isogenic control, Abs. Collectively, these data support an important
role for
M-CSF and monocytes in
VEGF production and angiogenesis
Okazaki et al., J Immunol 2005
(Carcinoma, Lewis Lung...) :
In vivo,
M-CSF increased
VEGF mRNA expression in skeletal muscles ... Even after treatment with carageenan and anti-CD11b mAb in mice,
M-CSF increased
VEGF production in skeletal muscles, suggesting that systemic VEGF elevation was attributed to skeletal muscle VEGF production ... In vitro,
M-CSF increased
VEGF production and activated the Akt signaling pathway in C2C12 myotubes
Varney et al., J Interferon Cytokine Res 2005
(Melanoma...) :
Next, we examined the
effect of MCP-1 and
M-CSF on modulation of
VEGFA expression in monocytes/macrophages ... In summary, we demonstrate that MCP-1 and
M-CSF , critical for monocyte recruitment, activation, and differentiation, differentially
regulate VEGF-A expression and may play an important role in monocyte/macrophage- mediated tumor angiogenesis
Nakano et al., Stem Cells 2006
(Disease Models, Animal...) :
M-CSF augments the production of
vascular endothelial growth factor ( VEGF ) from the bone marrow cells, especially from myeloid lineage cells
Okazaki et al., Am J Pathol 2007
(Myocardial Ischemia...) :
Here, we show
M-CSF increases
VEGF production from cardiomyocytes, protects cardiomyocytes and myotubes from cell death, and improves cardiac function after ischemic injury ... In mice,
M-CSF increased
VEGF production in hearts and in freshly isolated cardiomyocytes, which showed M-CSF receptor expression ... In rat cell line H9c2 cardiomyocytes and myotubes,
M-CSF induced
VEGF production via the Akt signaling pathway, and M-CSF pretreatment protected these cells from H ( 2 ) O ( 2 ) -induced cell death