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IKBKB — VEGFA
Text-mined interactions from Literome
Dikov et al., Cancer Res 2001
:
However, although TNF-alpha induced rapid activation of
IkappaB kinase (IKK) as expected, this activity was substantially reduced in the
presence of
VEGF
Kiriakidis et al., J Cell Sci 2003
(Inflammation...) :
VEGF expression in human macrophages is NF-kappaB
dependent : studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the
IkappaB kinase 2
Maeng et al., Cell Signal 2006
:
Using two PKC inhibitors has demonstrated that
VEGF concomitantly
stimulates IKK and its negative regulatory signal ERK through PKC that lies downstream of KDR/Flk-1
Tong et al., Respir Res 2006
:
In addition, HIMF strongly induced Akt phosphorylation, and suppression of Akt activation by specific inhibitors and dominant negative mutants for PI-3K, and
IKK or IkappaBalpha blocked HIMF induced NF-kappaB activation and
attenuated HIMF induced
VEGF production