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IL1B — VEGFA
Text-mined interactions from Literome
Maruyama et al., J Mol Cell Cardiol 1999
(Second Messenger Systems) :
Interleukin-1 beta upregulates cardiac expression of
vascular endothelial growth factor and its receptor KDR/flk-1 via activation of protein tyrosine kinases
Akagi et al., Br J Cancer 1999
(Colonic Neoplasms) :
Regulation of
vascular endothelial growth factor expression in human colon cancer by
interleukin-1beta ... We investigated
interleukin-1beta (IL-1beta) induction of
VEGF expression in colon cancer cells and the mechanism by which this occurs ...
IL-1beta induction of
VEGF was also confirmed at the protein level ... To examine the mechanism for
VEGF induction by
IL-1beta , we transiently transfected VEGF promoter-reporter constructs into HT29 cells ... These findings suggest that
IL-1beta regulates
VEGF expression in human colon cancer cells by increasing transcription of the VEGF gene
Levitas et al., J Soc Gynecol Investig 2000
:
Periovulatory and
interleukin-1 beta dependent up-regulation of intraovarian
vascular endothelial growth factor ( VEGF ) in the rat : potential role for VEGF in the promotion of periovulatory angiogenesis and vascular permeability ... It is tempting to speculate that the up-regulatory
effect of
IL-1 beta on
VEGF transcripts may be relevant to the marked angiogenesis and increased vascular permeability displayed by the hyperemic ovarian Graafian follicle during the terminal stages of follicular development
Cho et al., J Immunol 2000
(Arthritis, Rheumatoid) :
Stimulation of FLS with TNF-alpha,
IL-1beta , and TGF-beta
increased VEGF production by 1.6-, 2.0-, and 5.2-fold, respectively, and displayed an additive effect on the production of VEGF by CD40L
El Awad et al., Kidney Int 2000
(Anoxia...) :
Hypoxia and
interleukin-1beta stimulate
vascular endothelial growth factor production in human proximal tubular cells
Sunder et al., Baillière's best practice & research. Clinical obstetrics & gynaecology 2000
:
IL-1beta , expressed by the blastocyst,
induces vascular endothelial growth factor ( VEGF ) which, in turn, promotes angiogenesis and integrin expression in endometrial cells
Tanaka et al., J Mol Cell Cardiol 2000
(MAP Kinase Signaling System) :
Induction of
VEGF gene transcription by
IL-1 beta is mediated through stress activated MAP kinases and Sp1 sites in cardiac myocytes ... In this study, we examined the
effects of
IL-1 beta on the expression of vascular endothelial cell growth factor (
VEGF ) and pursued the molecular mechanisms underlying this effect ... Transient transfection assays showed that
IL-1 beta increases the transcription from the
VEGF promoter ... A series of 5 ; -deletion and site-specific mutation analyses indicated that
IL-1 beta as well as overexpression of p38 MAPK and JNK
activate VEGF promoter activity through two G+C-rich sequences located at -73 and -62 ... Together, these results indicate that
IL-1 beta induces
VEGF gene expression at both transcriptional and post-transcriptional levels, and IL-1 beta evokes p38 MAPK and JNK signalings, which in turn stimulate the transcription of the VEGF gene through Sp1 binding sites
Parry et al., Exp Nephrol 2001
:
In contrast, TBF-beta and
IL-1beta caused an increase in
VEGF production
Dulak et al., Atherosclerosis 2001
:
In rat, VSMC
IL-1beta induced NO generation and enhanced
VEGF synthesis ... 7-Kchol decreased rat iNOS promoter activity, iNOS expression and NO generation, but it did not impair
IL-1beta induced
VEGF synthesis
Jung et al., Angiogenesis 2001
:
We previously demonstrated that
interleukin-1 beta (IL-1 beta) leads to induction of
vascular endothelial growth factor ( VEGF ) in human colon carcinoma cells ... As pericytes play a role in regulating EC function, we hypothesized that
IL-1 beta may
mediate EC survival by induction of
VEGF in a paracrine manner ... We investigated the
effects of
IL-1 beta on
VEGF expression in human VSMCs ( hVSMCs ) and the signal transduction pathways that may be involved ... These data demonstrate that
IL-1 beta may
induce VEGF in hVSMCs, and suggest that this paracrine signaling pathway, may prevent, in part, apoptosis of ECs
Alber et al., J Am Coll Cardiol 2002
(Coronary Disease) :
In vitro, atorvastatin decreased both the basal and the
interleukin-1beta induced
VEGF release in HCASMC
Hitchon et al., Arthritis Rheum 2002
(Anoxia...) :
VEGF production was potently
induced by TGFbeta, and to a lesser extent by
IL-1beta and TNF, and was further augmented by hypoxia
Choi et al., Am J Reprod Immunol 2002
:
These results suggest that
IL-1beta , IFN-gamma, and TNF-alpha may
regulate the production of
VEGF in early gestational trophoblasts
Koyama et al., Eur Respir J 2002
:
Interleukin
(IL)-1beta and tumour necrosis factor (TNF)-alpha
augmented the release of
VEGF in a time- and dose dependent manner
Jung et al., FASEB J 2003
(Inflammation...) :
We find that
IL-1beta up-regulated HIF-1alpha protein under normoxia and
activated the HIF-1-responsive gene
vascular endothelial growth factor ( VEGF ) via a pathway dependent on nuclear factor kappaB (NFkB)
Gutsche et al., Mol Hum Reprod 2003
:
Epithelial mRNA expression of
IL-1beta , IL-6 and LIF
increased by stimulation with TGF-beta1 and IL-8, but not with
VEGF
Qian et al., Biol Reprod 2004
(MAP Kinase Signaling System) :
Meanwhile,
IL-1 beta also
induced the secretion of
VEGF in normal human cytotrophoblast cells ... These data indicate that, in normal human cytotrophoblast cells,
IL-1 beta induces HIF- 1 alpha mediated
VEGF secretion and that IL-1 beta stimulated ERK1/2 activation may be involved in this process
Pufe et al., J Pathol 2004
(Osteoarthritis) :
Furthermore,
VEGF induced
IL-1beta , IL-6, TNF-alpha, and nitric oxide expression to a small extent and stimulated the proliferation of immortalized chondrocytes
Fan et al., Cancer Res 2004
:
We previously demonstrated that
IL-1beta regulates
VEGF expression in tumor cells
Distler et al., Circ Res 2004
(Scleroderma, Systemic) :
Considering our observation that PDGF and
IL-1beta costimulated
VEGF expression, we propose that chronic and uncontrolled VEGF upregulation that is mediated by an orchestrated expression of cytokines rather than VEGF downregulation is the cause of the disturbed vessel morphology in the skin of SSc patients
Honorati et al., Osteoarthritis Cartilage 2004
(Arthritis, Rheumatoid...) :
IL-17,
IL-1beta and TNF-alpha
stimulate VEGF production by dedifferentiated chondrocytes ... In differentiated conditions
IL-1beta and TNF-alpha, but not IL-17, can
inhibit the spontaneous secretion of
VEGF by human OA, RA and FP chondrocytes, and IL-17 can restore the decrease in VEGF secretion caused by TNF-alpha ... IL-17, together with
IL-1beta and TNF-alpha, can
enhance VEGF secretion to various extents by dedifferentiated OA chondrocytes
Shinji et al., Am J Physiol Gastrointest Liver Physiol 2005
:
These results suggest that IL-1beta induced mPGES-1 protein expression preferentially coupled with COX-2 protein at late stages of PGE2 production and that
IL-1beta stimulated
VEGF production was totally dependent on membrane associated proteins involved in eicosanoid and glutathione metabolism ( MAPEG ) superfamily proteins, which includes mPGES-1, but was partially dependent on the COX-2/PGE2 pathway
Faffe et al., Am J Physiol Lung Cell Mol Physiol 2005
:
Oncostatin M (OSM), but not other IL-6 family cytokines, increased
VEGF release, and
IL-1beta enhanced OSM induced VEGF release ...
IL-1beta did not augment the effects of OSM on VEGF promoter activity but did
augment OSM induced
VEGF mRNA expression and mRNA stability ... In contrast, inhibitors of MAPK pathway had no effect on OSM or OSM plus
IL-1beta induced
VEGF release ... Consistent with the increase in IL-1R1 expression, OSM markedly augmented
IL-1beta induced
VEGF , MCP-1, and IL-6 release ... IL-1beta also synergizes with OSM to increase VEGF release, likely as a result of
effects of
IL-1beta on
VEGF mRNA stability as well as effects of OSM on IL-1R1 expression
Asano-Kato et al., Exp Eye Res 2005
:
TGF-beta1,
IL-1beta , and Th2 cytokines
stimulate vascular endothelial growth factor production from conjunctival fibroblasts ... TGF-beta1,
IL-1beta , and Th2 cytokines from allergic inflammatory cells
induced VEGF production in conjunctival fibroblasts, and may play a crucial role in neovascularization and formation of giant papillae in AKC/VKC
Stocks et al., FEBS Lett 2005
:
Here, we report that
vascular endothelial growth factor ( VEGF ) -A secretion by human airway smooth muscle cells was
increased by
interleukin 1 beta (IL-1beta) and transforming growth factor beta ( TGFbeta ) ... Both
IL-1beta and TGFbeta
increased VEGF-A ( 165 ) mRNA and
VEGF promoter luciferase construct activity, in addition VEGF-A protein was inhibited by actinomycin D suggesting transcriptional regulation ... In conclusion,
IL-1beta increases
VEGF-A secretion by COX-2 derived PGE ( 2 ) production whereas TGFbeta uses COX independent pathways
Stadlmann et al., Gynecol Oncol 2005
(Ovarian Neoplasms...) :
VEGF secretion in OVCA cells was also
increased by
IL-1beta ( 514 +/- 105 pg/10 ( 5 ) cells ; P < 0.01 ) or TNF-alpha ( 458 +/- 168 pg/10 ( 5 ) cells ; P < 0.01 ) reaching similar levels as in IL-1beta activated HPMC
Konishi et al., Oncology 2005
(Carcinoma...) :
We investigated the expression of
VEGF induced by
IL-1beta in five colon cancer cell lines and the possible involvement of IL-1 RA ...
IL-1beta induced
VEGF secretion with a 19-fold increase in Caco-2 cells ... IL-1 RA inhibited
IL-1beta induced
VEGF secretion by 87 % ... Our data suggest that
IL-1beta induces
VEGF expression and IL-1 RA acts as the competitive inhibitor, and that the IL-1 RA/IL-1beta ratio is significant for VEGF expression in the microenvironment of colorectal cancer tissue ... We conclude that
IL-1beta induces
VEGF secretion in a certain population of colorectal cancer patients, and that IL-1 RA is the potential therapeutic agent for antiangiogenic therapy in colorectal cancer patients
Itakura et al., Graefes Arch Clin Exp Ophthalmol 2006
(Anoxia) :
Triamcinolone acetonide suppresses
interleukin-1 beta mediated increase in
vascular endothelial growth factor expression in cultured rat Müller cells ... Stimulation of Müller cells by either
IL-1b or hypoxia
induced VEGF mRNA expression ... Pretreatment of cells with TA efficiently suppressed
VEGF induction by
IL-1b but not by hypoxia ... RNA decay assays and promoter analysis of the VEGF gene indicated that TA inhibited the
IL-1b mediated increase in
VEGF gene expression at the transcriptional level ... TA suppressed
VEGF expression
induced by
IL-1b in Müller cells at the transcriptional level
Pulsatelli et al., Clin Exp Rheumatol 2005
(Osteoarthritis, Knee) :
VEGF production by osteoartritis ( OA ) chondrocytes was significantly
reduced by
IL-1beta while it was increased in the presence of TGFbeta
Mayr et al., Circ Res 2006
(Arteriosclerosis) :
Additionally, iNOS-deficient SMCs showed a low level of
VEGF production in
response to
interleukin 1beta stimulation
Hayashi et al., J Obstet Gynaecol Res 2006
:
The production of
VEGF , bFGF and TGF-beta respectively was
enhanced by both
IL-1beta and TNF-alpha
Kalinski et al., Cancer 2006
(Chondroma...) :
Differential expression of
VEGF-A and angiopoietins in cartilage tumors and
regulation by
interleukin-1beta ... As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling, we further analyzed the
effect of
IL-1beta on the expression of
VEGF-A , Ang-1, and Ang-2 using a previously established cell culture model ...
IL-1beta regulated
VEGF-A and Ang-1 expressions in a dose dependent manner
Kimura et al., Br J Pharmacol 2006
(Burns) :
3. In human keratinocyte cultures ( HaCaT cells ), ginsenoside Rb1 ( 100 fg ml(-1) to 1 ng ml(-1) ) enhanced
VEGF production
induced by
IL-1beta and expression of hypoxia-inducible factor (HIF)-1alpha
Kalinski et al., Hum Pathol 2007
(Bone Neoplasms...) :
We further used a chondrosarcoma cell line to study the
effect of interleukin
(IL)-1beta and hypoxia on the regulation of ADAMTS1 and
VEGF-A expression
Yoshino et al., Int J Oncol 2006
(Brain Neoplasms...) :
IL-1beta significantly
stimulated VEGF secretion in these glioma cells ... The levels of
IL-1beta in U87MG were significantly higher than in other glioma cell lines, and IL-1 receptor antagonist
suppressed basal secretion of
VEGF from U87MG
Argaw et al., J Immunol 2006
(Anoxia...) :
Suggesting functional significance, we found that expression of
IL-1beta in the brain
induced astrocytic expression of HIF-1alpha,
VEGF-A , and BBB permeability
Solà-Villà et al., Kidney Int 2006
:
IL-1beta induces
VEGF , independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells ... In the present work, we studied the
effect of
IL-1beta on
VEGF release by rat mesangial cells, the transduction signal, and whether or not PGE2 is involved in this effect ... Indomethacin exerted a nonsignificant effect on
IL-1beta induced
VEGF , and exogenously added PGE2 exhibited a nonsignificant stimulatory effect on VEGF formation ... SB 203580, a p38 mitogen activated protein kinase inhibitor, weakly inhibited the
induction of
VEGF by
IL-1beta in a concentration dependent manner, whereas LY 294002, a phosphoinoside 3-kinase (PI3-K) inhibitor, and rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, strongly inhibited both IL-1beta- and tumor necrosis factor-alpha induced VEGF formation in a concentration dependent manner
Nasu et al., Gynecol Endocrinol 2006
:
Interleukin-1beta regulates
vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts ... The aim of the present study was to evaluate the
effects of interleukin
(IL)-1beta on the production of vascular endothelial growth factor (
VEGF ) and soluble fms-like tyrosine kinase-1 ( sFlt-1 ) in the human fallopian tube ... The secretion of
VEGF and sFlt-1 by cultured OECs and OSFs in
response to
IL-1beta and IL-1 receptor antagonist (IL-1RA) was measured using an enzyme linked immunosorbent assay ...
IL-1beta induced production of
VEGF and sFlt-1 by these cells was significantly inhibited by the addition of IL-1RA
Hosokawa et al., Clin Exp Immunol 2006
(Periodontitis) :
The IL-8 and
VEGF production induced by TWEAK was augmented synergistically by simultaneous
stimulation with transforming growth factor (TGF)-beta1 or
IL-1beta
Ray et al., J Immunol 2007
(Arthritis...) :
Deletion of SAF-1 binding elements from the VEGF promoter as well as knockdown of endogenous SAF-1 markedly inhibited
IL-1beta- and TGF-beta mediated
induction of
VEGF expression in chondrocyte cells
Rega et al., Arterioscler Thromb Vasc Biol 2007
:
Furthermore,
IL-1beta synergistically
enhanced the effect of OSM on
VEGF production
Nakao et al., Am J Pathol 2007
(Corneal Neovascularization) :
Here, we show that dexamethasone inhibits
IL-1beta induced neovascularization and the expression of the angiogenesis related factors,
vascular endothelial growth factor-A , KC, and prostaglandin E ( 2 ) in the mouse cornea 2 days after IL-1beta implantation ... Furthermore, dexamethasone inhibited
IL-1beta induced expression of
vascular endothelial growth factor-A , KC, and prostaglandin E ( 2 ), and signaling of nuclear factor (NF)-kappaB in corneal fibroblasts in vitro
Tsuji et al., Int Immunopharmacol 2007
:
Bucillamine mechanism inhibiting
IL-1beta induced
VEGF production from fibroblast-like synoviocytes ... We investigated the bucillamine ( Buc ) mechanism inhibiting interleukin
(IL)-1beta induced
vascular endothelial growth factor ( VEGF ) production from human fibroblast-like synoviocytes ( HFLS ) which derived from the inflamed synovium of an RA patient using SA981, its active metabolite ... While SA981 partially inhibited
IL-1beta induced
VEGF production at concentrations of 10 to 100 microM ( 10.1 % and 14.2 % inhibition of total VEGF production under IL-1beta coexistence condition, respectively ), it failed to inhibit IL-1beta induced IL-6 production at the same concentrations
Hirose et al., Cell Transplant 2008
(Ischemia) :
Expression of basic fibroblast growth factor (bFGF) and
vascular endothelial growth factor ( VEGF ) of mRNA in P-MNCs was apparently enhanced by hypoxic stimulation, and the production of VEGF protein was also
augmented by hypoxia and
IL-1beta
Lee et al., Int Immunopharmacol 2009
(Arthritis, Rheumatoid...) :
Flavonol-rich RVHxR and fisetin significantly decreased
IL-1beta induced inflammatory cytokines ( TNF-alpha, interleukin (IL)-6 ) /chemokines ( IL-8, monocyte chemoattractant protein (MCP)-1 ), and
vascular endothelial growth factor ( VEGF ) of RA FLS
Lu et al., Invest Ophthalmol Vis Sci 2009
(Burns, Chemical...) :
Moreover, IL-1 alpha and
IL-1 beta enhanced
VEGF and iNOS expression by murine peritoneal macrophages
Murayama et al., Cell Biol Int 2010
:
Effect of
VEGF ( vascular endothelial growth factor ) on expression of IL-8 ( interleukin-8 ),
IL-1beta and their receptors in bovine theca cells ... Secondly, we examined the
effects of
VEGF on the expression of IL-8,
IL-1beta and their receptors genes in cultured bovine theca cells
Yudoh et al., Int J Rheum Dis 2009
(MAP Kinase Signaling System...) :
Chondrocytes were stimulated with or without
IL-1beta ( 10 ng/mL ) in the
presence or absence of
vascular endothelial growth factor , basic fibroblast growth factor or hepatocyte growth factor ( 20 ng/mL )
Perera et al., Arthritis Res Ther 2010
(Inflammation) :
However,
IL-1beta did not
induce SOX-9,
VEGF , and c-Myc gene expression and inhibited AC cell proliferation
Li et al., J Biol Chem 1995
:
Induction of
vascular endothelial growth factor gene expression by
interleukin-1 beta in rat aortic smooth muscle cells ... To determine whether
interleukin-1 beta (IL-1 beta) , which is present in atherosclerotic lesions,
induces VEGF gene expression in vascular smooth muscle cells, we performed RNA blot analysis on rat aortic smooth muscle cells ( RASMC ) with a rat VEGF cDNA probe ...
IL-1 beta increased
VEGF mRNA levels in RASMC in a time- and dose dependent manner ... As little as 0.1 ng/ml
IL-1 beta increased
VEGF mRNA levels by 2-fold and 10 ng/ml IL-1 beta increased VEGF mRNA by 4-fold ... We also measured the half-life of VEGF mRNA and performed nuclear run-on experiments before and after addition of IL-1 beta to see if
IL-1 beta increased
VEGF mRNA levels by stabilizing the mRNA or by increasing its rate of transcription ... The normal, 2-h half-life of VEGF mRNA in RASMC was lengthened to 3.2 h ( 60 % ) by IL-1 beta, and
IL-1 beta increased the rate of
VEGF gene transcription by 2.1-fold ... In immunoblot experiments with an antibody specific for VEGF, we found that
IL-1 beta increased
VEGF protein levels in RASMC by 3.3-fold ... Together these data indicate that
IL-1 beta induces
VEGF gene expression in smooth muscle cells ... This
IL-1 beta induced expression of
VEGF may accelerate the progression of atherosclerotic lesions by promoting the development of new blood vessels
Cornali et al., Am J Pathol 1996
(Neovascularization, Pathologic...) :
Northern blot analysis as well as studies on single cells using in situ hybridization revealed that
VEGF expression in cultivated AIDS-KS spindle cells is
up-regulated by platelet derived growth factor-B and
interleukin-1 beta
Jackson et al., J Rheumatol 1997
(Arthritis, Rheumatoid...) :
Expression of
vascular endothelial growth factor in synovial fibroblasts is
induced by hypoxia and
interleukin 1beta ...
VEGF secretion was further
inducible by both hypoxia and
interleukin 1beta (IL-1beta) and these increases were additive