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ITGA5 — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of FN1-ITGA5-ITGB1 → VEGFA (increases)
  Evidence: The data in Figure 1D suggested that a second aV integ- rin, aVb5, which has been implicated in angiogenesis, may also be activated by VEGF165. Therefore, we sought concento determine if still other integrins implicated in angio- genesis, a5b1, a fibronectin receptor (Bloch et al., 1997), and a2b1, a collagen receptor (Senger et al., 1997), might be activated by VEGF165. In cell migration assays, VEGF165 markedly stimulated HUVEC movement onto effibronectin (see Figure 3A). The migrating cells e...
• OpenBEL Selventa BEL large corpus: Complex of ITGA5-ITGB1 → VEGFA (increases, VEGFA Activity)
  Evidence: The data in Figure 1D suggested that a second aV integ- rin, aVb5, which has been implicated in angiogenesis, may also be activated by VEGF165. Therefore, we sought concento determine if still other integrins implicated in angio- genesis, a5b1, a fibronectin receptor (Bloch et al., 1997), and a2b1, a collagen receptor (Senger et al., 1997), might be activated by VEGF165. In cell migration assays, VEGF165 markedly stimulated HUVEC movement onto effibronectin (see Figure 3A). The migrating cells e...
• OpenBEL Selventa BEL large corpus: Complex of ITGA5-ITGB1 → VEGFA (increases, VEGFA Activity)
  Evidence: VEGF enhanced cell adhesion, migration, soluble ligand binding, and adenovirus gene transfer mediated by alphavbeta3 and also activated other integrins, alphavbeta5, alpha5beta1, and alpha2beta1, involved in angiogenesis. The major findings of our studies are as follows. First, VEGF165 can activate integrin aVb3, leading to enhanced adhesion of endothelial cells to a variety of ligands.
• OpenBEL Selventa BEL large corpus: Complex of ITGA5-ITGB1 → VEGFA (increases, VEGFA Activity)
  Evidence: Fifth, VEGF165 activation is not targeted to a single integrin; b1 integrins, as exemplified by a5b1 and a2b1, also are affected by VEGF165 stimulation. In addition, our data suggest that aVb5 can be activated by the growth factor.

Text-mined interactions from Literome

Abumiya et al., J Cereb Blood Flow Metab 1999 (Brain Ischemia...) : In noncerebral vascular systems, VEGF can induce endothelial integrin alpha(v)beta3 expression
Lu et al., Mol Pharmacol 2006 : Laulimalide inhibited integrin activation ; however, compared with docetaxel, it had a weaker inhibitory effect on the VEGF induced association of VEGFR-2 with the alpha5beta1 integrin