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CCND1 — VHL

Text-mined interactions from Literome

Bindra et al., Cancer Res 2002 (Carcinoma, Renal Cell...) : VHL mediated hypoxia regulation of cyclin D1 in renal carcinoma cells ... This suggests a model whereby in some kidney cell types, pVHL may regulate a proliferative response to hypoxia, whereas the loss of pVHL leads to constitutively elevated cyclin D1 and abnormal proliferation under normal growth conditions
Zatyka et al., Cancer Res 2002 (Carcinoma, Renal Cell...) : A type 2C pVHL mutant ( V188L ), which is associated with a PHE only phenotype ( and had been shown previously to retain the ability to promote HIF ubiquitylation ), retained the ability to suppress CCND1expression suggesting that loss of pVHL mediated suppression of cyclin D1 is not necessary for PHE development in VHL disease
Baba et al., Oncogene 2003 (Carcinoma, Renal Cell...) : Taken together, these observations indicate that VHL is required for the downregulation of cyclinD1 at a high cell density through HIF