Blom et al., Arthritis Rheum 2009
(Arthritis, Experimental...) :
Adenoviral overexpression of WISP-1 in murine knee joints induced MMP and aggrecanase expression and resulted in cartilage damage
Reddy et al., J Cell Physiol 2011
(Hyperplasia) :
WISP1 also activated AP-1, but not NF-?B, and induced matrix metalloproteinase (MMP)9 transcription in part via AP-1