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ABCB1 — PIK3R1
Text-mined interactions from Literome
Kuo et al., Oncogene 2002
(Carcinoma, Hepatocellular) :
Transient transfection assays demonstrated that constitutively activated
PI3K and Rac1
enhanced the activation of the
MDR1 promoter by 2-AAF
Wang et al., Cancer Lett 2010
(Ovarian Neoplasms) :
Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes (
MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2, Bcl-xL and XIAP ), as well as
activation of Ras/MEK/ERK and
PI3K/Akt signaling
Mukherjee et al., Proc Natl Acad Sci U S A 2013
:
The innate immune receptor, Toll-like receptor 2/6 heterodimer, is exploited by Sb ( R ) LD to activate ERK and nuclear translocation of NF-?B involving p50/c-Rel leading to IL-10 induction, whereas
MDR1 up-regulation is
mediated by
PI3K/Akt and the JNK pathway