Gene interactions and pathways from curated databases and text-mining

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ABCC6 — CASP2

Text-mined interactions from Literome

Terrisse et al., Biochim Biophys Acta 2002 (Leukemia) : Furthermore, neither DNR or Ara-C induced caspase-8 activation
Kogoshi et al., Oncol Rep 2005 (Leukemia...) : To investigate the possible molecular mechanism of the protective effect, the influence of Jagged1 on Ara-C induced activation of caspase-3 and PARP, and dephosphorylation of NF-kappaB was examined in NB4 cells
Engelbrecht et al., J Mol Cell Cardiol 2005 (MAP Kinase Signaling System...) : EPA ( 20microM ) and ARA ( 20microM ) significantly inhibited caspase-3 activation and PARP-cleavage and reduced the apoptotic index during reperfusion
Kim et al., Cancer Res 1997 : In HL-60/neo cells, HIDAC induced progressive accumulation of cytochrome c in the cytosol, the decrease in deltapsi m, and the increase in reactive oxygen species were not inhibited by coculture with the tetrapeptide inhibitors of caspases that have been previously shown to inhibit Ara-C induced cleavage and activity of caspase-3 and apoptosis