Tang et al., Vasc Med 1999
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Basic FGF stimulates DNA synthesis and ACE mRNA expression, and both of these effects are reduced by an ACE inhibitor
Okabe et al., Biochem Biophys Res Commun 1987
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The stimulatory effect of FGF on ACE activity was dose dependent ( ED50 = 1.0 ng/ml )
Fishel et al., J Clin Invest 1995
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Among growth factors tested, only fibroblast growth factor ( FGF ) stimulated ACE expression ( 4.2 +/- 0.7-fold increase in activity and 1.6-fold increase in mRNA in response to 10 ng/ml FGF for 24 h ) ... The data suggest a temporal sequence for the response to injury in which FGF induces ACE , ACE generates angiotensin II, and angiotensin II stimulates VSMC growth in concert with FGF