Gene interactions and pathways from curated databases and text-mining

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ACHE — CASP7

Text-mined interactions from Literome

Toiber et al., PloS one 2008 (Alzheimer Disease) : In transfected primary brain cultures, N-AChE-S induced cell death, morphological impairments and caspase 3 activation
Zhang et al., Frontiers in molecular neuroscience 2012 : AChE plays a pivotal role in apoptosome formation, and silencing of the AChE gene prevents caspase-9 activation, with consequent decreased cell viability, nuclear condensation, and poly ( adenosine diphosphate-ribose ) polymerase cleavage
Zhang et al., Int J Biochem Cell Biol 2013 (Disease Models, Animal...) : In this study, we found that acetylcholinesterase protein expression increased and caspase-3 was activated in PC12 cells treated with 1-methyl-4-phenylpyridinium
Carvajal et al., J Alzheimers Dis 2013 (Alzheimer Disease...) : Finally, we found that the acute treatment of hippocampal neurons with THH, in the presence of Aß-AChE complexes, prevents 4-HNE adduct formation and caspase-3 activation