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ACIN1 — AKT2
Text-mined interactions from Literome
Chan et al., Cell Death Differ 2007
:
Thus,
Akt regulates
zyxin/acinus complex formation in the nucleus, contributing to suppression of apoptosis
Park et al., Eur J Cell Biol 2009
:
A critical role for
AKT activation in protecting cells from ionizing radiation induced apoptosis and the
regulation of
acinus gene expression ... The overexpression of
CA-AKT rendered the cells resistant to ionizing radiation and
prevented the proteolytic cleavage of
acinus via phosphorylation ... In addition, overexpression of
CA-AKT resulted in the upregulation of
acinus expression by activation of the NF-kappaB pathway ... On the other hand, suppression of endogenous
AKT expression by siRNA
resulted in the reduction of
acinus expression and enhanced the radiation induced apoptosis in both CCD-18Lu and IM-9 cells
Chan et al., Oncogene 2009
(Leukemia) :
NGF, a cognate ligand for the neurotrophic receptor TrkA, promotes the interaction between CtBP2 and acinus through
triggering acinus phosphorylation by
Akt