Gene interactions and pathways from curated databases and text-mining

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ACIN1 — AKT2

Text-mined interactions from Literome

Chan et al., Cell Death Differ 2007 : Thus, Akt regulates zyxin/acinus complex formation in the nucleus, contributing to suppression of apoptosis
Park et al., Eur J Cell Biol 2009 : A critical role for AKT activation in protecting cells from ionizing radiation induced apoptosis and the regulation of acinus gene expression ... The overexpression of CA-AKT rendered the cells resistant to ionizing radiation and prevented the proteolytic cleavage of acinus via phosphorylation ... In addition, overexpression of CA-AKT resulted in the upregulation of acinus expression by activation of the NF-kappaB pathway ... On the other hand, suppression of endogenous AKT expression by siRNA resulted in the reduction of acinus expression and enhanced the radiation induced apoptosis in both CCD-18Lu and IM-9 cells
Chan et al., Oncogene 2009 (Leukemia) : NGF, a cognate ligand for the neurotrophic receptor TrkA, promotes the interaction between CtBP2 and acinus through triggering acinus phosphorylation by Akt