Gene interactions and pathways from curated databases and text-mining

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ADAM12 — PIK3R1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Le Pabic et al., Hepatology 2003 (Colorectal Neoplasms...) : The PI3K inhibitor LY294002 and the mitogen activated protein kinase kinase ( MEK ) inhibitor UO126 prevented ADAM12 induction by TGF-beta, suggesting the involvement of PI3K and MEK activities
Le Pabic et al., J Hepatol 2005 : The involvement of PI3K in ADAM12 expression, similar to that previously observed for collagen I and fibronectin, suggests common pathways for gene up-regulation in hepatic stellate cells that occur during liver fibrogenesis and contribute to tumor progression