Gene interactions and pathways from curated databases and text-mining

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ADM — TGFB1

Text-mined interactions from Literome

Nishikimi et al., J Hypertens 2004 (Glomerulosclerosis, Focal Segmental...) : After 7 weeks, untreated DS were characterized by decreased kidney function, increased proteinuria, abnormal morphological findings, increased adrenomedullin and atrial natriuretic peptide (ANP) levels, and increased renal messenger RNA expression of RhoB, Rho-kinasealpha, Rho-kinasebeta, collagen I and collagen III, and transforming growth factor-beta ( TGF-beta ) in the renal cortex compared with DR. Chronic fasudil treatment significantly improved renal function ( serum creatinine, -26 % ; blood urea nitrogen, -41 % ; creatinine clearance, +42 % ), proteinuria ( -24 % ) and histological findings ( glomerular injury score, -49 % ; afferent arteriolar injury score, -17 % ) without changing blood pressure compared with untreated DS
Liu et al., Zhonghua Xin Xue Guan Bing Za Zhi 2007 : The AngII induced type I, III collagen secretion in adventitial fibroblasts was significantly reduced by AMD in a dose dependent manner, ( P < 0.01 ) while ADM agonist ADM ( 22 - 52 ) significantly potentiated the effect of AngII ; ADM also reduced AngII induced expression of TGFbeta1 at mRNA and protein levels in a dose dependent manner
Nagae et al., Kidney Int 2008 (Fibrosis...) : In NRK-49F renal fibroblasts, adrenomedullin reduced transforming growth factor-beta induced CTGF and fibronectin mRNA upregulation through the cyclic AMP/protein kinase A signaling pathway, and suppressed ERK phosphorylation and cell proliferation